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山东大学学报 (医学版) ›› 2025, Vol. 63 ›› Issue (11): 53-60.doi: 10.6040/j.issn.1671-7554.0.2022.0302

• 临床医学 • 上一篇    

耳穴电针联合高频重复经颅磁刺激对卒中后抑郁的疗效

王立童1,2,王战2,吴静仪2,吴艳盈2,李永娜3,唐洪1   

  1. 1.大连理工大学医学部生物医学工程学院, 辽宁 大连 116024;2.大连医科大学附属第二医院康复科, 辽宁 大连 116031;3.大连普兰店老年病医院康复科, 辽宁 大连 116200
  • 发布日期:2025-11-28
  • 通讯作者: 唐洪. E-mail:tanghong@dlut.edu.cn
  • 基金资助:
    国家自然科学基金(61971089,61471081);大连市科技创新基金(2021JJ12WZ47)

Effect of ear acupoint electroacupuncture combined with high-frequency repetitive transcranial magnetic stimulation on post-stroke depression

WANG Litong1,2, WANG Zhan2, WU Jingyi2, WU Yanying2, LI Yongna3, TANG Hong1   

  1. 1. School of Biomedical Engineering, School of Medicine, Dalian University of Technology, Dalian 116024, Liaoning, China;
    2. Rehabilitation Department of the Second Affiliated Hospital of Dalian Medical University, Dalian 116031, Liaoning, China;
    3. Rehabilitation Department of Dalian Pulandian Geriatric Hospital, Dalian 116020, Liaoning, China
  • Published:2025-11-28

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摘要： 目的 观察耳穴电针联合高频重复经颅磁刺激(repetitive transcranial magnetic stimulation, rTMS)对卒中后抑郁患者的效果,为临床治疗提供新方案。 方法 选取2023年2月至2024年12月就诊于大连医科大学附属第二医院的卒中后抑郁患者140例,随机分成对照组(34例)、耳穴电针组(36例)、rTMS组(33例)和耳穴联合rTMS组(37例);比较各组患者汉密尔顿抑郁量表-17(Hamiltons Depression Scale-17, HAMD-17)、抑郁自评量表(Self-Rating Depression Scale, SDS)、蒙特利尔认知评估量表(Montreal Cognitive Assessment, MoCA)、改良Barthel指数(Modified Barthel Index, MBI)量表、临床神经功能缺损量表(Clinical Neurological Deficit Scale, CNDS)得分以及5-羟色胺(5-hydroxytryptmine, 5-HT)和血清脑源性神经营养因子(brain-derived neuro-trophic factor, BDNF)水平。 结果 与治疗前相比,各组患者治疗后HAMD-17、SDS评分和CSS评分均减少,差异有统计学意义(P<0.05);MoCA、MBI评分增加,差异有统计学意义(P<0.05),5-HT和BDNF水平增加,差异有统计学意义(P<0.05)。与对照组相比,耳穴联合rTMS组、耳穴电针组、rTMS组HAMD-17、SDS评分和CSS评分减少,差异有统计学意义(P<0.05);MBI评分增加,差异有统计学意义(P<0.05);5-HT和BDNF水平增加,差异有统计学意义(P<0.05)。耳穴联合rTMS组患者的上述评分和指标优于其他2个观察组,差异有统计学意义(P<0.05)。 结论 耳穴电针联合高频rTMS可显著改善卒中后抑郁患者的各项指标。

关键词: 脑卒中, 抑郁, 耳穴电针, 重复经颅磁刺激

Abstract: Objective To observe the efficacy of ear-point electroacupuncture combined with high-frequency repetitive transcranial magnetic stimulation(rTMS)on patients with post-stroke depression, thereby providing a new clinical treatment regimen. Methods A total of 140 patients with post-stroke depression, who attended the Second Affiliated Hospital of Dalian Medical University from February 2023 to December 2024, were randomly divided into a control group and three experimental groups(ear-point electroacupuncture group, rTMS group, and ear-point combined with rTMS group). The patients scores on the Hamilton Depression Scale-17(HAMD-17), Self-Rating Depression Scale(SDS), Montreal Cognitive Assessment(MoCA), Modified Barthel Index(MBI), and Clinical Neurological Deficit Scale(CNDS), as well as the levels of 5-hydroxytryptamine(5-HT)and brain-derived neurotrophic factor(BDNF)were compared. Results After treatment, significant reductions were observed in HAMD-17, SDS, and CNDS scores(P<0.05), with significant increases in MoCA and MBI scores(P<0.05), and elevated levels of 5-HT and BDNF(P<0.05), in all groups compared to pre-treatment. The ear-point combined with rTMS group, ear-point electroacupuncture group, and rTMS group showed more significant reductions in HAMD-17, SDS, and CNDS scores, and increases in MBI scores and 5-HT and BDNF levels, compared to the control group(P<0.05). The ear-point combined with rTMS group demonstrated superior outcomes in these measures compared to the other two experimental groups(P<0.05). Conclusion Ear-point electroacupuncture combined with high-frequency rTMS significantly improves various indicators in patients with PSD.

Key words: Stroke, Depression, Ear acupoint electroacupuncture, Repetitive transcranial magnetic stimulation

中图分类号: 

  • R741
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