成年人全血γ-干扰素释放试验检测结果与年龄的相关性

doi:10.6040/j.issn.1671-7554.0.2015.493

摘要/Abstract

摘要： 目的通过对成年人年龄与全血γ-干扰素释放试验(QFT-GIT)检测结果的相关性分析,探讨年龄与成年人全血γ-干扰素释放水平之间的关系。方法将168名QFT-GIT检测结果阳性人群分为18~40、41~65、>65岁组,比较各年龄组TB抗原特异性γ-干扰素释放水平(TB Ag-Nil)的变化趋势,以及植物血凝素刺激的非特异性γ-干扰素释放水平(Mitogen-Nil)的变化趋势。采用Spearman方法分析T细胞对结核特异性抗原应答、丝裂原免疫应答与年龄的相关性,采用线性回归分析TB Ag-Nil、Mitogen-Nil水平随年龄的变化趋势。结果 18~40和41~65岁年龄组TB Ag-Nil和Mitogen-Nil值的变化无统计学意义(P>0.05);>65岁年龄组TB Ag-Nil和Mitogen-Nil值随年龄的增长明显降低(P<0.05)。结论在18~65岁的成年人,QFT-GIT检测结果与年龄无统计学相关;超过65岁后,TB Ag-Nil和Mitogen-Nil与年龄均呈负相关。

关键词: 结核分枝杆菌, 全血γ-干扰素释放试验, 年龄

Abstract: Objective To explore the relationship between age and release of interferon gamma in blood of adults through the correlation analysis of age and QuantiFERON-TB gold in-tube test(QFT-GIT)results. Methods A total of 168 patients with positive results of QFT-GIT were divided into three groups according to the age:18 to 40 years group, 41 to 65 years group and elder than 65 years group. The changes of IFN-γ response to TB-specific antigen(TB Ag-Nil)and non-specific phytohemagglutinin(Mitogen-Nil)were compared among the three groups. Spearman correlation analysis was used to calculate the correlation coefficient value γ. Linear regression analysis was used to show the change. Results The change trend of TB Ag-Nil and Mitogen-Nil in 18 to 40 years group and 41 to 65 years group were not statistically significant(P>0.05). However in patients elder than 65 years, the levels of TB Ag-Nil and Mitogen-Nil decreased significantly with age increasing(P<0.05). Conclusion For patients of 18 to 65 years, the results of QFT-GIT are not related to the age, but for those elder than 65 years, TB Ag-Nil and Mitogen-Nil is negatively related to the age.

Key words: Mycobacterium, QuantiFERON-TB gold in-tube test, Age

中图分类号:

R446.61

卜范峰,孙霞霞,梁晓玲. 成年人全血γ-干扰素释放试验检测结果与年龄的相关性[J]. 山东大学学报（医学版）, 2016, 54(6): 87-90.

BU Fanfeng, SUN Xiaxia, LIANG Xiaoling. Correlation of QuantiFERON-TB gold in-tube test result with age of adults[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 87-90.

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