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山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (10): 45-48,60.doi: 10.6040/j.issn.1671-7554.0.2014.342

• 临床医学 • 上一篇    下一篇

进展性脑梗死患者血清Hs-CRP、SAA水平变化及意义

李宁1, 邓红琼1, 王翠兰2   

  1. 1. 济南市第三人民医院神经内科, 山东 济南 250101;
    2. 山东大学齐鲁医院神经内科, 山东 济南 250012
  • 收稿日期:2014-05-27 修回日期:2014-09-25 出版日期:2014-10-10 发布日期:2014-10-10
  • 通讯作者: 李宁。E-mail：lyn-kallen@163.com E-mail:lyn-kallen@163.com

Changes and significance of serum Hs-CRP and SAA in patients with progressive cerebral infarction

LI Ning1, DENG Hongqiong1, WANG Cuilan2   

  1. 1. Department of Neurology, Jinan Third People's Hospital, Jinan 250101, Shandong, China;
    2. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-05-27 Revised:2014-09-25 Online:2014-10-10 Published:2014-10-10

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摘要： 目的 探讨进展性脑梗死（PCI）患者血清超敏C反应蛋白（Hs-CRP）、血清淀粉样蛋白A（SAA）水平变化及临床意义。方法 选取34例PCI患者为PCI组，33例非进展性脑梗死（NPCI）患者为NPCI组，34例针对血管危险因素查体者为对照组。通过胶乳增强免疫比浊法检测血清Hs-CRP水平，酶联免疫吸附法（ELISA）检测SAA水平，并对患者采用斯堪的纳维亚卒中量表（SSS）进行评分。结果 相较于NPCI组、对照组，PCI组患者在入院1、3、7、14 d血清Hs-CRP、SAA水平明显升高（P均<0.01），且上述蛋白水平呈正相关（P<0.01）。此外，PCI患者第1天血清Hs-CRP、SAA水平与入院第3、21天时SSS评分均呈明显负相关（P均<0.05）。结论 PCI患者血清Hs-CRP、SAA水平明显升高，其早期水平与病情程度密切相关，提示血清Hs-CRP和SAA水平在PCI的临床进程中均起重要作用，这为PCI诊断及治疗提供了新思路。

关键词: 进展性脑梗死, 非进展性脑梗死, 血清淀粉样蛋白A, 超敏C-反应蛋白

Abstract: Objective To investigate changes and significance of serum high-sensitivity C-reactive protein (Hs-CRP) and serum amyloid A protein (SAA) in patients with progressive cerebral infarction (PCI). Methods A total of 107 participants were divided into 3 groups: PCI group (n=34), non-progressive cerebral infarction (NPCI) group (n=33) and control group (people with vascular risk factors who received clinical examinations, n=34). Hs-CRP levels were measured with immune nephelometry, and SAA levels were evaluated with enzyme-linked immunosorbent assay (ELISA). Patients were rated with the Scandinavian Stroke Scale (SSS) score. Results Compared with the NPCI group and controls, the Hs-CRP and SAA levels in the PCI group significantly increased on day 1, 3, 7, and 14 (all P<0.01). In the PCI group, Hs-CRP and SAA levels were positively correlated (P<0.01), and Hs-CRP and SAA levels one day 1 were negative correlated with the SSS on day 3 and 21 (all P<0.05). Conclusion Levels of Hs-CRP and SAA are significantly enhanced in PCI patients, which are closely related with the severity of disease, suggesting that Serum Hs-CRP and SAA play an important role in the progression of PCI.

Key words: Non-progressive cerebral infarction, Serum amyloid A protein, Progressive cerebral infarction, High-sensitivity C-reactive protein

中图分类号: 

  • R741
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