IgA、CD35在慢性扁桃体炎和IgAN患者扁桃体中表达的临床病理学意义

山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (7): 92-95.

IgA、CD35在慢性扁桃体炎和IgAN患者扁桃体中表达的临床病理学意义

宫丽丽1，侯森2，任玉波3，李连庆1，王晶1，张廷国4

1.聊城市人民医院眼耳鼻喉医院，山东聊城 252000； 2.阳谷县人民医院耳鼻喉科，山东阳谷 252300；
3.聊城市人民医院病理科，山东聊城 252000； 4.山东大学医学院病理学教研室，济南 250012

收稿日期:2013-01-14 出版日期:2013-07-10 发布日期:2013-07-10
通讯作者: 张廷国， E-mail:ztguo@sdu.edu.cn

Clinical and pathological significances of the expressions of IgA and CD35 in chronic tonsillitis and IgAN patients’ tonsillae

GONG Li-li1， HOU Sen2， REN Yu-bo3， LI Lian-qing1， WANG Jing1， ZHANG Ting-guo4

1. Ophthalmological and Otolaryngological Hospital, Liaocheng People′s Hospital, Liaocheng 252000, Shandong China;
2. ENT department, Yanggu People′s Hospital, Yanggu 252300, Shandong， China;
3. Department of Pathology, Liaocheng People′s Hospital, Liaocheng 252000, Shandong, China;
4. Department of Pathology, School of Medicine, Shandong University, Jinan 250012, China

Received:2013-01-14 Online:2013-07-10 Published:2013-07-10

摘要/Abstract

摘要：

目的探讨IgA、CD35在慢性扁桃体炎和IgA肾病(IgA-N)患者扁桃体中的表达及其意义，以及两种患者扁桃体中IgA和CD35表达的差异。方法采用Elivisiontm Plus法对37例IgA-N患者和80例慢性扁桃体炎患者切除的扁桃体标本均行IgA和CD35免疫组化染色，光学显微镜下对免疫组化病理切片阳性细胞进行计数，采用假设检验计量资料的t检验对IgA、CD35在两种扁桃体疾病中表达的阳性细胞数行统计学分析。结果 IgA和CD35在IgA-N患者的扁桃体中表达均呈强阳性反应，且呈正相关；在慢性扁桃体炎患者的扁桃体中阳性表达明显减少，染色强度亦明显降低。结论 IgA和CD35在慢性扁桃体炎和IgA-N两种疾病的扁桃体中的阳性表达具有差异性。在慢性扁桃体炎的扁桃体IgA、CD35免疫组化阳性表达，可能是隐匿性IgA-N发生的早期事件之一，可作为早期诊断IgA-N的指标之一。

关键词: IgA肾病；扁桃体； IgA；CD35免疫标记物

Abstract:

Objective To observe the expression and significance of IgA and CD35 in chronic tonsillitis and IgA-N patients, and to explore the difference of IgA and CD35 expressions in the two kinds of patients′ tonsillae. Methods Tonsillar specimens of 37 IgA-N patients and 80 chronic tonsillitis patients were examined by immunohistochemical staining with IgA and CD35. Positive staining cells were counted under the light microscope, and statistical analysis of IgA and CD35 positive staining cells was carried out by t-test. Results The expressions of IgA and CD35 in IgA-N tonsillae were strongly positive and presented positive correlation. The positive expressions of IgA and CD35 in chronic tonsillitis tonsillae significantly reduced. Conclusion There were significant differences of IgA and CD35 expressions in chronic tonsillitis and IgA-N patients. The expressions of IgA and CD35 in chronic tonsillitis may be one of the earlier period events, and can be the index for the early diagnosis of IgA-N.

Key words: IgA nephropathy; Tonsilla; IgA; CD35

中图分类号:

R365

宫丽丽1，侯森2，任玉波3，李连庆1，王晶1，张廷国4. IgA、CD35在慢性扁桃体炎和IgAN患者扁桃体中表达的临床病理学意义[J]. 山东大学学报(医学版), 2013, 51(7): 92-95.

GONG Li-li1， HOU Sen2， REN Yu-bo3， LI Lian-qing1， WANG Jing1， ZHANG Ting-guo4. Clinical and pathological significances of the expressions of IgA and CD35 in chronic tonsillitis and IgAN patients’ tonsillae[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(7): 92-95.

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