3598株临床分离病原菌的分布及耐药性

山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (7): 87-91.

3598株临床分离病原菌的分布及耐药性

郭爱萍1，于秀娟2，刘新风1，王德景1，郑文1

1.山东省交通医院检验科, 济南 250031； 2.济南银丰医学检验中心, 济南 250031

收稿日期:2012-12-11 出版日期:2013-07-10 发布日期:2013-07-10
通讯作者: 郭爱萍， E-mail：guoaiping0604@163.com

Distribution and antibiotic resistance of 3598 clinic isolated pathogenic bacteria

GUO Ai-ping1, YU Xiu-juan2, LIU Xin-feng1, WANG De-jing1, ZHENG Wen1

1. Department of Clinical Laboratory, Shandong Traffic Hospital, Jinan 250031, China；
2. Yinfeng Clinical Laboratory Center, Jinan 250031, China

Received:2012-12-11 Online:2013-07-10 Published:2013-07-10

摘要/Abstract

摘要：

目的了解临床分离病原菌的分布及对抗菌药物的耐药性，指导临床合理用药。方法回顾性分析2010年5月至2012年4月临床分离的3598株病原菌及药敏结果。结果 3598株病原菌中革兰阴性杆菌2895株(80.5%)，其中大肠埃希菌784株(21.9%)、铜绿假单胞菌703株(19.6 %)、肺炎克雷伯菌462株(12.8 %)、鲍曼不动杆菌399株(11.1%)，大肠埃希菌和肺炎克雷伯菌产超广谱β内酰胺酶(ESBLs)检出率分别为55.5%、31.0%，两者对亚胺培南、美罗培南的敏感率均为100%，对头孢哌酮/舒巴坦、阿米卡星的敏感率较高，大肠埃希菌为99.23%、91.96%，肺炎克雷伯菌为98.92%、92.21%；铜绿假单胞菌对头孢哌酮/舒巴坦、阿米卡星、头孢吡肟的敏感率较高分别为91.75%、90.18%、89.47%；鲍曼不动杆菌对头孢哌酮/舒巴坦、米诺环素、氨苄西林/舒巴坦的敏感率较高分别为97.99%、93.48%、84.71%。革兰阳性球菌556株(15.5%)，其中金黄色葡萄球菌139株(3.9%)、凝固酶阴性葡萄球菌116株(3.2%)、粪肠球菌141株(4.0%)、屎肠球菌101株(2.8%)；耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的检出率分别为21.6%和56.0%，未检出耐万古霉素葡萄球菌和耐万古霉素肠球菌。真菌147株(占4.1%)。结论了解病原菌的分布并动态监测其耐药性，可指导临床合理使用抗菌药物，并有效控制和减缓细菌耐药的产生。

关键词: 病原菌；分布；耐药性；抗菌药物；多药耐药

Abstract:

Objective To investigate the distribution and antibiotic resistance of bacteria isolated from clinical samples and to guide reasonable clinical treatment of antibiotics. Methods 3598 strains of bacteria with their drug sensitivity test results during May 2010 to Apr. 2012 were reviewed retrospectively. Results In 3598 strains of pathogenic bacteria, 2895 (80.5%) strains were gram-negative bacilli which containedd 784( 21.9%)strains of Escherichia coli， 703(19.6%) strains of Pseudomonas aeruginosa， 462(12.8%) strains of Klebsiella pneumoniae, 399 (11.1%) strains of Acinetobacter baumannii. The positive rate of extendedspectrum β-lactamases from Escherichia coli and Klebsiella pneumoniae were 55.5% and 31.0%, respectively. Both of them were 100% sensitive to imipenem and meropenem, highly sensitive to cefoperazone/sulbactam and amikacin. The sensitivity of Escherichia coli were 99.23% and 91.96%, and the sensitivity of Klebsiella pneumoniae were 98.92% and 92.21%. The sensitivity of pseudomonas aeruginosa to cefoperazone/sulbactam， amikacin and cefepime were 91.75%， 90.18% and 89.47%, respectively. The sensitivity of Acinetobacter baumannii to cefoperazone/sulbactam， minocycline and ampicillin/sulbactam were 97.99%， 93.48% and 84.71%, respectively. There were 556 strains of gram-positive cocci(15.5%) which contained 139 strains of Staphylococcus aureus(3.9%)、 116 strains of coagulase-negative Staphylococci (3.2%)， 141 strains of Enterococcus faecalis (4.0%) and 101 strains of Enterococcus faecium (2.8%). The detection rate of MRSA and MRCNS were 21.6% and 56.0%, respectively. No strains of Staphylococcus and Enterococcus with resistance to vancomycin were detected.There were 147(4.1%) strains of fungi. Conclusion To understand the distribution of pathogen bacteria and monitor its drug resistance dynamically can guide the reasonable use of antibiotics as well as control and delay the emergence of drug resistant strains.

Key words: Pathogens； Distribution； Antibiotic resistance； Antibiotics； Multidrugresistant

中图分类号:

郭爱萍1，于秀娟2，刘新风1，王德景1，郑文1. 3598株临床分离病原菌的分布及耐药性[J]. 山东大学学报(医学版), 2013, 51(7): 87-91.

GUO Ai-ping1, YU Xiu-juan2, LIU Xin-feng1, WANG De-jing1, ZHENG Wen1. Distribution and antibiotic resistance of 3598 clinic isolated pathogenic bacteria[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(7): 87-91.

参考文献

相关文章 15

[1]	习海波,傅龙龙,王共先,傅斌,李煜,宋小芬. 尿激酶3′-UTR 基因多态性与特发性草酸钙结石易感性的关系[J]. 山东大学学报(医学版), 2013, 51(5): 105-107.
[2]	邢海燕1,2，薛凤华3，秦晓敏4，张建平1,4. HIF-1α、VEGF和MMP-9在子宫内膜样腺癌中的表达及临床意义[J]. 山东大学学报(医学版), 2013, 51(4): 77-80.
[3]	张永振，陈修德，孙鹏，尉春晓，钟浩，金讯波. 侧卧位经皮肾镜碎石术治疗ESWL失败的输尿管上段结石（附53例报告）[J]. 山东大学学报(医学版), 2013, 51(4): 105-107.
[4]	张晶1，王春妮2，戚美2，王妍3，刘龙3，韩博2，3. 二烯丙三硫对乳腺癌MDA-MB-231细胞增殖和侵袭的抑制及对uPA系统的调节[J]. 山东大学学报(医学版), 2012, 50(10): 61-.
[5]	王昕1，王健2，刘言训1，贾崇奇1. 山东省3县农村居民被动吸烟情况研究[J]. 山东大学学报(医学版), 2012, 50(4): 110-.
[6]	蒋立城1，2，徐忠华1，张英晨2，王学廷2，丁吉阳2，程玉峰2. 非增强螺旋CT定位联合C臂微创经皮肾镜取石治疗复杂肾结石[J]. 山东大学学报(医学版), 2012, 50(3): 71-.
[7]	李晓红1，胡立宽1,2，王翠红1，杜元娜1. Glu-GNPs对人肺腺癌细胞株A549放射增敏的初步探讨[J]. 山东大学学报(医学版), 2012, 50(3): 29-.
[8]	柳俊杰1，王健1，刘言训2，贾崇奇2. 山东省三县农村卫生机构控烟现状分析[J]. 山东大学学报(医学版), 2012, 50(3): 125-.
[9]	陈红, 刘庆华, 郭海生, 李芳, 康艳萌, 林殿杰. IL-6和sE-选择素与肺炎病情及预后的相关性分析[J]. 山东大学学报(医学版), 2012, 50(2): 82-.
[10]	李晓林，杨倩倩，刘金之，王爱华. 他罗利姆对氯化锂-匹鲁卡品癫痫持续状态炎性因子表达的影响[J]. 山东大学学报(医学版), 2012, 50(2): 11-15.
[11]	黄方1, 张勇1，黄建强1，黄斯诚2. 鼻腔、鼻窦内翻性乳头状瘤中G3BP、Stathmin的表达及意义[J]. 山东大学学报(医学版), 2011, 49(11): 120-.
[12]	吴臣永1,2，王青1，展新风1，王芳1. 磁共振成像在胎儿泌尿系统异常诊断中的应用[J]. 山东大学学报(医学版), 2011, 49(11): 142-.
[13]	赵保明1，李凤良2，宋喜明1. 糖基化终末产物对人内皮细胞分泌前列环素和内皮素-1的影响[J]. 山东大学学报(医学版), 2011, 49(11): 5-7.
[14]	崔晓萍1，林航1，陈建梅2，穆军山1，叶建新1，殷红兵1，应大君3. 低氧对体外培养的神经干细胞中Wnt/β-catenin 信号通路相关分子表达的影响[J]. 山东大学学报(医学版), 2010, 48(9): 44-48.
[15]	江文静1，杜滨锋2，迟兆富3，麻琳1，单培彦1，张旭华4. 难治性癫痫大鼠海马线粒体蛋白质的差异表达[J]. 山东大学学报(医学版), 2010, 48(9): 53-58.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed