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山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (7): 70-74.

• 临床医学 • 上一篇    下一篇

胰腺癌根治术后淋巴结总数及阴性淋巴结数与预后的相关性

徐阳1,曲辉2,孙国瑞2,何庆泗2   

  1. 山东大学 1.医学院; 2.齐鲁医院普外科, 济南 250012
  • 收稿日期:2012-10-10 出版日期:2013-07-10 发布日期:2013-07-10
  • 通讯作者: 何庆泗, E-mail:hingsisurgeon@163.com
  • 基金资助:

    山东省自然科学基金(Y2008C38)

Relationship of the number of all dissected and negative lymph  nodes to the prognosis of patients after pancreatic cancer radical surgery

XU Yang1, QU Hui2, SUN Guo-rui2, HE Qing-si2   

  1. 1. School of Medicine, Shandong University;
     2. General Surgery Department, Qilu Hospital of Shandong University,  Jinan 250012, China
  • Received:2012-10-10 Online:2013-07-10 Published:2013-07-10

摘要:

目的   探讨胰腺癌根治术后淋巴结总数及阴性淋巴结数与预后的关系。方法   回顾性分析山东大学齐鲁医院1998~2007年胰腺癌根治术227例患者的临床资料。探讨淋巴结总数及阴性淋巴结数目与预后的相关性。结果   共182例获得随访,随访率为80.2%。无淋巴结转移患者76例,3、5年生存率分别为28.9%、21.0%,淋巴结总数为影响预后的独立因素。有淋巴结转移患者106例,3、5年生存率分别为21.1%、7.5%。淋巴结总数及阴性淋巴结数为影响预后的独立因素。淋巴结总数及阴性淋巴结数具有明显相关性(r=0.919,P<0.05)。结论   在根治性手术规范化进行的前提下,可将淋巴结总数及阴性淋巴结数作为胰腺癌患者TNM分期的预后判断辅助指标,使得患者获得更准确的临床分期和预后判断,以期获得最佳远期疗效。

关键词: 胰腺肿瘤;淋巴结;影响因素;相关性;预后

Abstract:

Objective   To assess the relationship of all dissected and negative lymph nodes number to the prognosis of patients after pancreatic cancer radical surgery. Methods   Two hundred and twenty-seven  patients with pancreatic carcinoma who underwent radical resection from 1998 to 2007 in Qilu Hospital of Shandong University were involved. The relationship of the all dissected and negative LNs number to the survival of patients was analyzed. Results   A total of 182 patients were obtained with the follow-up rate of 80.2%. There were 76 patients with no lymph node metastasis. The 3-year survival rate and 5-year survival rate was 28.9% and 21.0% respectively. The number of all dissected LNs was the independent predictor. The 3-year survival rate and 5-year survival rate of the rest 106 patients with lymph node metastasis was 21.1% and 7.5%. The numbers of all dissected LNs and negative LNs were independent predictors. The all dissected LNs number was positively correlated with negative LNs number on the Pearson's correlation test(r=0.919, P<0.05). Conclusion   With the standard radical surgery, the all dissected LNs and negative LNs numbers can be TNM stage auxiliary indicators for the prognosis of pancreatic cancer patients, so that patients can get more accurate clinical stages and prognostic judgment and the best longterm survival rate.

Key words: Pancreatic neoplasm; Lymph node; Influencing factor; Relevance; Prognosis

中图分类号: 

  • R657.5
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