关键词: 周围神经损伤；神经生长因子；纤维蛋白胶；神经修复；临床疗效

Abstract:

Objective   To retrospectively analyze the clinical efficacy of anastomosis of peripheral nerve embedded by fibrin glue containing nerve growth factor. Methods   The data of 76 hospitalized patients in our hospital from January 2006 to December 2011 were collected and analyzed. They were divided into two groups (20062007 for the control group, and 20082011 for the treatment group). Epineurium anastomosis was used in the control group and the stoma of the nerve was coated by fibrin glue containing nerve growth factor in the treatment group. We analyzed the clinical efficacy by the results of the clinical manifestations and electromyogram(EMG). Results   The efficacy rate and excellence rate of sensory function assessment were 75.00% and 45.00% in the control group, and 86.96% and 69.56% in the treatment. The efficacy rate and excellence rate of motor function assessment were 72.50% and 45.00% in the control group, and 86.96% and 65.22% in the treatment group. The efficacy rate and excellence rate of clinical curative effect were 72.50% and 47.50% in the control group, and 86.96% and 67.39% in the treatment group. The efficacy rate and excellence rate of EMG recovery assessment were 72.50% and 47.50% in the control group, and 86.96% and 69.57% in the treatment group. The two groups had significant differences in all the above indicators(all P<0.05). Conclusion   The method of anastomosis of peripheral nerve embedded by fibrin glue containing nerve growth factor can promote the recovery of neural function, and it is a better way to repair injured peripheral nerve.

Key words: Peripheral nerve injury; Nerve growth factor; Fibrin glue; Nerve repair; Clinical curative effects