乙肝病毒感染不同阶段血清HBsAg定量值及其与HBV DNA水平和年龄的相关性

山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (5): 94-98.

乙肝病毒感染不同阶段血清HBsAg定量值及其与HBV DNA水平和年龄的相关性

符晓莉，王磊，刘峰

山东大学第二医院感染/肝病科，济南 250033

收稿日期:2013-01-07 出版日期:2013-05-10 发布日期:2013-05-10
通讯作者: 王磊， E-mail: wlcrb@sdu.edu.cn
基金资助:
艾滋病和病毒性肝炎等重大传染病防治“十一五”国家科技重大专项(2009ZX10002028)

HBsAg quantitative value in different stages of hepatitis B virus infection and its correlations with serum HBV DNA and age

FU Xiao-li， WANG Lei， LIU Feng

Department of Infection/Liver Diseases, The Second Hospital of Shandong University, Jinan 250033, China

Received:2013-01-07 Online:2013-05-10 Published:2013-05-10

摘要/Abstract

摘要：

目的研究未经抗病毒治疗干预的慢性乙肝病毒(HBV)感染不同阶段血清乙肝表面抗原(HBsAg)定量值的特点及其与血清HBV DNA水平和年龄的相关性。方法收集564例未经抗病毒治疗的慢性HBV感染者血清，分为6组：慢性HBV携带65例，非活动性HBsAg携带164例，e抗原(HBeAg)阳性慢性乙型肝炎171例，HBeAg阴性慢性乙型肝炎74例，HBeAg阳性乙肝肝硬化42例，HBeAg阴性乙肝肝硬化48例。采用微粒子化学发光法检测HBsAg定量值，荧光PCR定量法检测血清HBV DNA水平。结果慢性HBV携带、HBeAg阳性慢性乙型肝炎、HBeAg阴性慢性乙型肝炎、非活动性HBsAg携带、HBeAg阴性肝硬化和HBeAg阳性肝硬化6组的血清HBsAg定量值依次下降，其中位数分别为：4.71(3.71～5.31)、4.04(2.45～5.22)、3.50(2.68～4.43)、3.34(1.38～4.37)、3.25(1.85～3.88) 和3.15(2.51～3.92) lgIU/mL，６组间比较差异有统计学意义(χ2=263.0，P＜0.001)。总慢性HBV感染者(非活动性HBsAg携带者除外)的HBsAg与HBV DNA呈正相关(r=0.719，P＜0.001)，总慢性HBV感染者的HBsAg与年龄呈负相关(r=-0.397，P＜0.001)。年龄均＞40岁的非活动性HBsAg携带与HBeAg阴性慢性乙型肝炎两组HBsAg定量值的差异有统计学意义(Z=-3.783，P＜0.001)，区分两组的HBsAg定量临界值为3.29lgIU/mL。结论慢性HBV感染不同阶段的HBsAg定量值不同；血清HBsAg定量值与血清HBV DNA水平及年龄相关；HBsAg定量值是预测年龄＞40岁的非活动性HBsAg携带是否发展为HBeAg阴性慢性乙型肝炎的重要指标。

关键词: 表面抗原定量；慢性乙型肝炎；乙型肝炎病毒；年龄

Abstract:

Objective To investigate the baseline HBsAg quantification of different phases of hepatitis B virus infection without antiviral treatment and the relationships of HBsAg with HBV DNA and age. Methods Five hundred and sixty-four HBV-infected patients without accepting antiviral therapy were divided into 6 groups according to the phase of HBV-infection: chronic HBV-carrier (65 patients), inactive HBsAg carrier (164 patients), HBeAg-positive chronic hepatitis B (171 patients), HBeAg-negative chronic hepatitis B (74 patients), HBeAg-positive hepatitis B liver cirrhosis(42 patients)and HBeAg-negative hepatitis B liver cirrhosis(48 patients). Serum HBsAg was quantified using the Abbott ARCHITECT platform and HBV DNA by real-time fluorescence quantitative PCR method. Results The HBsAg median levels in groups of chronic HBV-carrier, HBeAg-positive chronic hepatitis B, HBeAg-negative chronic hepatitis B, inactive HBsAg carrier, HBeAgnegative hepatitis B liver cirrhosis and HBeAg-positive hepatitis B liver cirrhosis were 4.71(3.71-5.31), 4.04(2.45-5.22), 3.50(2.68-4.43), 3.34(1.38-4.37), 3.25(1.85-3.88) and 3.15(2.51-3.92) lgIU/mL, respectively. Statistical difference of HBsAg was found among the 6 groups (χ2=263.0，P＜0.001). HBsAg quantification (excepting inactive HBsAg carrier) was positively correlated with HBV DNA (r=0.719，P＜0.001). Negative correlation was found between HBsAg and age(r=-0.397，P＜0.001). In patients older than 40 years, HBsAg quantification was statistically different between inactive HBsAg carrier group and HBeAgnegative chronic hepatitis B group (3.14/3.53lgIU/mL, P＜0.001), and the cut-off value was 3.29lgIU/mL. Conclusion HBsAg quantification is distributed differently in the different phases of HBV-infection. Serum HBsAg is correlated with HBV DNA and age. HBsAg quantitative value is an important indicator to predict whether the inactive HBsAg carriers develop to the HBeAg- negative chronic hepatitis B.

Key words: Quantification of surface antigen； Chronic hepatitis B； Hepatitis B virus； Age

中图分类号:

R512.6

符晓莉，王磊，刘峰. 乙肝病毒感染不同阶段血清HBsAg定量值及其与HBV DNA水平和年龄的相关性[J]. 山东大学学报(医学版), 2013, 51(5): 94-98.

FU Xiao-li， WANG Lei， LIU Feng. HBsAg quantitative value in different stages of hepatitis B virus infection and its correlations with serum HBV DNA and age[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(5): 94-98.

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