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山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (5): 66-70.

• 临床医学 • 上一篇    下一篇

纯母乳喂养对妊娠期糖尿病患者产后糖脂代谢和体成分的影响

唐林凤1,高燕燕1,林慧2,姚培培1   

  1. 1.青岛大学医学院附属医院东区内分泌科, 山东 青岛 266100;
    2.青岛市妇女儿童医院,山东 青岛 266000
  • 收稿日期:2012-12-27 出版日期:2013-05-10 发布日期:2013-05-10
  • 通讯作者: 高燕燕, E-mail:qdygyy@126.com

Effects of exclusive lactation on glucose and lipid metabolism, body composition in gestational diabetes patients after pregnancy

TANG Lin-feng1, GAO Yang-yang1, LIN Hui2, YAO Pei-pei1   

  1. 1. Department of Endocrinology, East Hospital of Affliated Hospital of Medical College,
    Qingdao University, Qingdao 266100, Shandong, China;
    2. Qingdao Women and Children’s Hospital, Qingdao 266000, Shandong, China
  • Received:2012-12-27 Online:2013-05-10 Published:2013-05-10

摘要:

目的   探讨纯母乳喂养对妊娠期糖尿病(GDM)患者产后糖、脂代谢和体成分的影响。方法   选取80例GDM患者,根据产后母乳喂养情况分为纯母乳喂养组和混合喂养组,测定产前和产后第42天口服葡萄糖耐量试验(OGTT)、血脂谱、胰岛素及产后24h内和第42天体成分。结果   58例患者完成观察,其中纯母乳喂养组30例,产后42d较产前OGTT血糖、胰岛素值和胆固醇(TC)、低密度脂蛋白胆固醇(LDL)水平均明显降低(P<0.05),胰岛素敏感指数(ISI)明显升高(P<0.01);较产后24h内的基础代谢明显增加(P<0.01)、内脏脂肪等级降低(P<0.05)。混合喂养组28例,产后42d较产前空腹血糖(FBG)、OGTT 2h血糖(2hPG)降低(P<0.05),而其余指标均无明显变化(P>0.05)。产后42d时纯母乳喂养组较混合喂养组血糖、胰岛素及血脂、内脏脂肪等级均明显低(P<0.05),ISI和基础代谢明显高(P<0.01)。结论   GDM患者产后进行纯母乳喂养可以有效改善其糖、脂代谢,提高胰岛素敏感性,降低胰岛素抵抗,改善脂代谢;并有利于提高基础代谢率和减少内脏脂肪。

关键词: 纯母乳喂养;妊娠期糖尿病;糖、脂代谢;体成分

Abstract:

Objective   To investigate the effects of exclusive breastfeeding postpartum on the glucose, lipid metabolism and body composition of patients with gestational diabetes mellitus (GDM). Methods   80 cases of women with GDM were divided into the exclusive breastfeeding group and the mixed feeding group according to the postpartum feeding patterns. Oral glucose tolerance test(OGTT), fasting serum lipids and insulin were examined prepartum and on the 42nd day postpartum; body composition was examined on the first and the 42nd day postpartum. Results   After 42 days lactation, 58 cases finished the research (30 in the exclusive breastfeeding group, 28 in the mixed feeding group). In the exclusive breastfeeding group, OGTT blood glucose, insulin, TC and LDL significantly decreased after 42 days lactation (P<0.05), accompanied by the increase in ISI and basal metabolism (P<0.01) and decrease in visceral fat (P<0.05). In the mixed feeding group, the FBG and 2hPG decreased (P<0.05), but the other indexes showed no obvious change (P>0.05). Compared with those of the mixed feeding group, the exclusive breastfeeding group’s FBG, insulin and serum lipid were significantly lower (P<0.05), ISI was significantly higher (P<0.01), of body composition, the visceral fat was significantly lower (P<0.05) and basal metabolism was significantly higher(P<0.01) on the 42nd day postpartum. Conclusion   Exclusive breastfeeding postpartum has beneficial effects on the glucose,  lipid meta-bolism of patients with GDM. It can increase insulin sensitivity and also helps to lower IR, elevate basal metabolism and reduce visceral fat.

Key words: Exclusive breastfeeding; Gestational diabetes mellitus; Glucose and lipid metabolism; Body composition

中图分类号: 

  • R589
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