着色性干皮病基因D Lys751Gln多态性与非霍奇金淋巴瘤临床表型及化疗疗效的相关性

山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (4): 62-66.

着色性干皮病基因D Lys751Gln多态性与非霍奇金淋巴瘤临床表型及化疗疗效的相关性

廖小莉1，谢伟敏2，胡晓桦1，李永强1，刘志辉1，陆永奎2，王洪学2

广西医科大学附属肿瘤医院 1.化疗一科； 2.化疗五科，南宁 530021

收稿日期:2012-12-05 出版日期:2013-04-10 发布日期:2013-04-10
通讯作者: 谢伟敏(1969- )，男，硕士，副主任医师，副教授，主要从事肿瘤内科临床与基础研究。E-mail: xieweimin3358@163.com
作者简介:廖小莉(1978- )，女，硕士，主治医师，主要从事肿瘤内科临床与基础研究。E-mail:nllxl@163.com
基金资助:
广西科学基金资助项目(桂科基0342010-7)

Correlations between gene polymorphisms of xeroderma pigmentosum gene D Lys751Gln and clinical phenotypes and chemotherapeutic effects of non-Hodgkin’s lymphoma

LIAO Xiao-li1, XIE Wei-min2, HU Xiao-hua1, LI Yong-qiang1, LIU Zhi-hui1,LU Yong-kui2, WANG Hong-xue2

1. The First Department of Chemotherapy; 2. The Fifth Department of Chemotherapy,
Tumor Hospital Affiliated to Guangxi Medical University, Nanning 530021, China

Received:2012-12-05 Online:2013-04-10 Published:2013-04-10

摘要/Abstract

摘要：

目的探讨着色性干皮病基因D(XPD)Lys751Gln多态性与非霍奇金淋巴瘤(NHL)临床表型及化疗疗效的相关性。方法收集87例广西NHL患者的外周血样本，检测XPD Lys751Gln位点的基因多态性，并分析各基因型与NHL临床表型及化疗疗效的相关性。结果 ① XPD Lys751Gln(T＞G)多态性位点在87例NHL患者中的基因型频数分布为：T/T基因型71例(81.6%)，T/G基因型16例(18.4%)，未发现G/G基因型；② T/T及T/G基因型的频率在不同NHL细胞来源组、不同肿瘤恶性程度组、有无B症状组、不同国际预后指数组分布均无统计学差异(P＞0.05)；③ T/T及T/G基因型的频率在化疗有效与无效患者之间的分布无统计学差异(P＞0.05)。结论在中国广西NHL患者中，XPD基因Lys751Gln多态性与NHL不同临床表型(细胞来源、肿瘤恶性程度、有无B症状、危险程度)及化疗疗效均无统计学相关性。

关键词: 非霍奇金淋巴瘤；基因；着色性干皮病；单核苷酸多态性

Abstract:

Objective To explore the correlations between gene polymorphisms of xeroderma pigmentosum gene D (XPD) Lys751Gln and different clinical phenotypes and chemotherapeutic effects of non-Hodgkin’s lymphoma (NHL). Methods Peripheral blood samples of 87 NHL patients from Guangxi of China were collected. The gene polymorphism of XPD Lys751Gln was detected, and the correlations between different gene types, NHL clinical phenotypes and chemotherapeutic effects were analyzed. Results ① Among 87 NHL patients, T/T and T/G genotypes of XPD Lys751Gln (T＞G) polymorphism sites were found in 71 cases (81.6%) and 16 cases (18.4%) respectively, but G/G genotype was not found. ② TT and TG genotype frequencies of XPD Lys751Gln showed no significant differences in the distributions of different NHL cell source groups, different malignant degree groups, with/without B symptom groups and different international prognostic index (IPI) groups (P＞0.05). ③ The distributions of TT and TG genotype frequencies between NHL patients with/without chemotherapeutic effects had no significant differences (P＞0.05). Conclusion Among NHL patients from Guangxi of China, there are no conspicuous associations between the XPD Lys751Gln polymorphism and different clinical phenotypes (cell source, malignant degree of tumors, with/without B symptom and dangerous degrees) and response to chemotherapy.

Key words: Non-Hodgkin’s lymphomas; Gene; Xeroderma pigmentosum; Single nucleotide polymorphism

中图分类号:

R733.1

廖小莉1，谢伟敏2，胡晓桦1，李永强1，刘志辉1，陆永奎2，王洪学2. 着色性干皮病基因D Lys751Gln多态性与非霍奇金淋巴瘤临床表型及化疗疗效的相关性[J]. 山东大学学报(医学版), 2013, 51(4): 62-66.

LIAO Xiao-li1, XIE Wei-min2, HU Xiao-hua1, LI Yong-qiang1, LIU Zhi-hui1,LU Yong-kui2, WANG Hong-xue2. Correlations between gene polymorphisms of xeroderma pigmentosum gene D Lys751Gln and clinical phenotypes and chemotherapeutic effects of non-Hodgkin’s lymphoma[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(4): 62-66.

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