关键词: 糖化低密度脂蛋白；冠脉造影阴性；糖尿病；冠脉粥样硬化

Abstract:

Objective   To investigate the relationship  between  glycosylated low density lipoprotein (G-LDL) degree of  coronary angiography.  MethodsWith reference to the results of coronary angiography examination, we selected 49 diabetic patients with negative coronary angiography results (DM-NCHD), 50 diabetic patients with positive coronary angiography results (DM-CHD), and 50 non-diabetic patients with negative coronary angiography results (NC). The G-LDL levels of the three groups were detected with nitrotetrazolium blue chloride. The diagnostic performance and optimum diagnostic boundary values of G-LDL in serum were evaluated with receiver operating characteristic curve (ROC curve). Results   G-LDL level of the DM-NCHD group was lower than that of the DM-CHD group (P<0.05), and tended to be higher compared to that of the NC group (P<0.05). When G-LDL level was 50.45, the sensitivity and specificity were 0.80 and 0.84, respectively. The G-LDL level in the DM-CHD group was positively correlated with the degree of coronary atherosclerosis (r=0.638, P=0.001). Conclusion    The G-LDL level in the DM-NCHD group is significantly lower than that in the DM-CHD group, and the G-LDL level in the DM-CHD group is positively correlated with the degree of coronary atherosclerosis, which indicates G-LDL may be an effective indicator to evaluate the risk of coronary atherosclerotic in patients with diabetes mellitus.

Key words: Glycosylated low density lipoprotein; Angiographically normal coronary arteries; Diabetes mellitus; Atherosclerosis