32P敷贴结合无针缝合器治疗前胸瘢痕疙瘩的疗效

山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (1): 88-92.

32P敷贴结合无针缝合器治疗前胸瘢痕疙瘩的疗效

李中华1，王海琴2，王一民1，杨波1，孙玉生1

1.济南市第四人民医院烧伤整形科，济南 250031； 2.济南市第五人民医院妇产科，济南 250021

收稿日期:2012-08-27 出版日期:2013-01-10 发布日期:2013-01-10
通讯作者: 孙玉生(1951- )，男，副主任医师，主要从事慢性溃疡和瘢痕治疗的研究。 E-mail：yuan2830@163.com
作者简介:李中华(1979- )，男，硕士，住院医师，主要从事瘢痕和干细胞组织工程的研究。 E-mail：jinansky@163.com

Clinical effect of 32P applicator combined with needleless skin instrument in the treatment of chest keloid

LI Zhong-hua1， WANG Hai-qin2, WANG Yi-min1, YANG Bo1, SUN Yu-sheng1

1. Department of Burns and Plastic Surgery, Jinan Fourth People’s Hospital, Jinan 250031, China;
2. Department of Obstetrics and Gynecology, Jinan Fifth People’s Hospital, Jinan 250021, China

Received:2012-08-27 Online:2013-01-10 Published:2013-01-10

摘要/Abstract

摘要：

目的探讨32P敷贴结合无针缝合器治疗前胸瘢痕疙瘩的临床疗效。方法回顾分析180例前胸瘢痕疙瘩患者治疗的疗效，其中将60例病变厚度≤0.2cm的患者随机分为3组，复方倍他米松注射组20例，单纯32P敷贴组20例，无针缝合器+32P敷贴组20例；120例病变厚度＞0.2cm的患者随机分为4组，复方倍他米松注射组30例，单纯32P敷贴组30例，手术+32P敷贴组30例，无针缝合器+手术+32P敷贴组30例。结果 ① 病变厚度≤0.2cm的患者中，复方倍他米松注射组的治愈率(35.0％)和有效率(55.0％)与单纯32P敷贴组的治愈率(75.0％)和有效率(85.0％)及无针缝合器+32P敷贴组的治愈率(80.0％)与有效率(90.0％)比较差异均有统计学意义(P<0．05)；② 病变厚度＞0.2cm的患者中，复方倍他米松注射组的治愈率(3.3％)和有效率(23.3%)与其他组比较差异均有统计学意义(P<0．05)；单纯32P敷贴组治愈率(20.0％)和有效率(53.3％)与无针缝合器+手术+32P敷贴组的治愈率(86.7％)和有效率(96.7％)及手术+32P敷贴组的治愈率(63.3％)与有效率(90.0％)比较差异均有统计学意义(P<0．05)；手术+32P敷贴组的治愈率与无针缝合器+手术+32P敷贴组比较差异有统计学意义(P<0．05)。结论病变厚度≤0.2cm的患者，可以单纯行32P敷贴治疗；病变厚度＞0.2cm的患者，建议手术切除后给予32P敷贴并结合使用无针缝合器治疗，效果较好。

关键词: 无针缝合器; 32P敷贴; 瘢痕疙瘩；复方倍他米松；张力

Abstract:

Objective To investigate the clinical efficacy of 32P applicator combined with needleless skin instrument for treating chest keloid． Methods Of all the 180 chest keloid patients, 60 with lesion thickness ≤0.2cm were randomly divided into three groups： 20 received compound betamethasone injection therapy, 20 received 32P applicator therapy, others were treated with 32P applicator combined with needleless skin instrument. 120 ones with lesion thickness >0.2cm were randomly divided into four groups: 30 received compound betamethasone injection therapy, 30 received 32P applicator therapy, 30 received operation combined with 32P applicator therapy， others were treated with operation combined with 32P applicator and needleless skin instrument. Results ① The cure rate and effective rate in the compound betamethasone injection group were 35.0% and 55.0%, which were significantly lower than those(75.0%, 85.0%)in the simple 32P application group and (80.0%, 90.0%)in the 32P applicator combined with needleless skin instrument group(P<0.05); ② The cure rate and effective rate in the compound betamethasone injection group were 3.3% and 23.3%, which were significantly lower than those in the other groups(P<0.05); The cure rate and effective rate in the simple 32P application group were 20.0% and 53.3%, which were significantly lower than those(86.7%, 96.7%) in the operation combined with 32P applicator and needleless skin instrument group and in the operation combined with 32P applicator group(P<0.05); The cure rate in the operation combined with 32P applicator and needleless skin instrument group was significantly higher than that in the operation combined with 32P applicator group(P<0.05). Conclusion For patients with lesion thickness ≤0.2cm， 32P applicator therapy only is enough． Otherwise， patients are suggested to use operation combined with 32P applicator and needleless skin instrument therapy.

Key words: Needleless skin instrument ; 32P applicator; Keloid ； Compound betamethasone; Tension

中图分类号:

R622+9

李中华1，王海琴2，王一民1，杨波1，孙玉生1. 32P敷贴结合无针缝合器治疗前胸瘢痕疙瘩的疗效[J]. 山东大学学报(医学版), 2013, 51(1): 88-92.

LI Zhong-hua1， WANG Hai-qin2, WANG Yi-min1, YANG Bo1, SUN Yu-sheng1. Clinical effect of 32P applicator combined with needleless skin instrument in the treatment of chest keloid[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(1): 88-92.

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