复方白芨胶/珍珠层粉修复兔牙槽骨缺损的实验研究

山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (1): 37-.

复方白芨胶/珍珠层粉修复兔牙槽骨缺损的实验研究

庞永志1，胡温庭2，彭凤梅3

1.潍坊医学院口腔医学院，山东潍坊 261053； 2.潍坊医学院附属医院口腔科，山东潍坊 261053；
3.山东大学附属千佛山医院口腔科，济南 250014

收稿日期:2012-08-22 出版日期:2013-01-10 发布日期:2013-01-10
通讯作者: 彭凤梅(1965- )，女，副教授，硕士生导师，主要从事口腔内科学的研究。 E-mail：pengfengmeisd@163.com
作者简介:庞永志(1986- )，男，硕士研究生，主要从事口腔颌面部组织缺损与重建的研究。 E-mail：pangyongzhisy@126.com
基金资助:
山东省自然科学基金(ZR2010HL014)

Experimental study of bletilla glucomannan/nacre powder composites repairing the alveolar bone defects in rabbits

PANG Yong-zhi1， HU Wen-ting2, PENG Feng-mei3

1. Oral Department of Weifang Medical College, Weifang 261053, Shandong, China;
2. Department of Dentistry, Affiliated Hospital of Weifang Medical College, Weifang 261053, Shandong, China;
3. Department of Dentistry, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, China

Received:2012-08-22 Online:2013-01-10 Published:2013-01-10

摘要/Abstract

摘要：

目的观测兔牙槽骨局部缺损后应用复方白芨胶/珍珠层粉的修复效果及复合材料降解吸收情况。方法 60只兔分3组，Ⅰ组：骨缺损处植入白芨胶/珍珠层粉复合材料；Ⅱ组：单纯珍珠层粉；Ⅲ组：不填充材料。分别在术后1、4、8、12周行影像学、骨密度、大体解剖学观察、组织学及碱性磷酸酶活性测定，评价骨缺损修复及材料降解情况。结果珍珠层粉与白芨胶粉生物相容性均良好，术后12周时各组材料均降解完成。Ⅰ组骨缺损修复最快。12周时Ⅰ组骨密度值为(0.41±0.02)g·cm-2，大于Ⅱ组，Ⅱ组大于Ⅲ组。术后各时间点碱性磷酸酶活性Ⅰ组最高。结论中药复方白芨胶/珍珠层粉能较快地修复局部牙槽骨缺损，为临床中药治疗牙槽骨缺损开辟了新方向。

关键词: 牙槽骨缺损；移植材料；生物相容性材料；白芨胶；纳米珍珠层粉

Abstract:

Objective To observe the repair effect and the degradation and absorption of the bletilla glucomannan/nacre powder composites in application of the rabbit alveolar bone’s local defect. Methods 60 rabbits were divided into 3 groups. GroupⅠ: defect was filled with bletilla glucomannan / nacre powder composites; Group Ⅱ: defect was filled with nacre powder; Group Ⅲ: defect was not filled with any implants. The effects were observed by imaging, bone mineral density(BMD), gross anatomy, histological, and alkaline phosphatase(ALP) at 1,4,8,12 weeks after surgery. Results The nacre powder and bletilla glucomannan had a good biocompatibility. Implant material of the three groups had an entirely degradation at 12 weeks after surgery. Group Ⅰ had a better osteogenesis ability than group Ⅱ and Ⅲ. The BMD(0.411±0.0188)g·cm-2of group Ⅰ was greater than that of group Ⅱ and the BMD of group II was greater than that of group Ⅲ at 12 weeks after surgery(P＜0.05). At the same postoperative time points, the ALP activity of the group Ⅰwas significantly greater than that of group Ⅱ and Ⅲ. Conclusion Chinese medicine bletilla glucomannan/pearl powder composites can repair partial alveolar bone defect quickly, and open up a new direction for Chinese medicine treatment of alveolar bone defect.

Key words: Alveolar bone defect; Graft material; Biocompatible material; Bletilla glucomannan; Nano-pearl powder

中图分类号:

R781.4

庞永志1，胡温庭2，彭凤梅3. 复方白芨胶/珍珠层粉修复兔牙槽骨缺损的实验研究[J]. 山东大学学报(医学版), 2013, 51(1): 37-.

PANG Yong-zhi1， HU Wen-ting2, PENG Feng-mei3. Experimental study of bletilla glucomannan/nacre powder composites repairing the alveolar bone defects in rabbits[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(1): 37-.

参考文献

相关文章 8

[1]	陈荟，郭泾. 猪脱细胞基质矿化支架材料的生物相容性及降解特性[J]. 山东大学学报(医学版), 2013, 51(5): 48-53.
[2]	刘文婷1，胡以俊1，陈丽2，姜广水1. 慢性牙周炎和2型糖尿病患者肠道柔嫩梭菌类群的定量分析[J]. 山东大学学报(医学版), 2013, 51(4): 100-104.
[3]	姚丽1，孙钦峰2，杨春惠1. 子痫前期伴牙周炎患者血清TNF-α、IL-6及CRP水平的检测[J]. 山东大学学报(医学版), 2012, 50(10): 123-126.
[4]	宗敏1，方冬冬1，高慧2，张君2,3. 正畸-牙周联合治疗中重度牙周炎早期牙周状况及龈沟液骨钙素水平变化的研究[J]. 山东大学学报(医学版), 2012, 50(1): 113-116.
[5]	刘梅1，张君2，王旭霞3. T1DM、T2DM糖尿病大鼠牙槽骨骨密度变化的相关性实验研究[J]. 山东大学学报(医学版), 2011, 49(9): 53-.
[6]	李雪1,林志勇1,赵芬1,赵民1,季梅1,于桂娜2，牟文丽3. 清热滋阴活血复方对大鼠糖尿病牙周炎的治疗作用及外周血IL-1β的影响[J]. 山东大学学报(医学版), 2010, 48(5): 72-74.
[7]	王磊1，张梅2，吴婷3，孙钦峰3，杨丕山3，魏奉才1. 冠心病伴牙周炎患者牙周状况及龈下菌斑的研究[J]. 山东大学学报(医学版), 2010, 48(3): 138-140.
[8]	田李静1，2，梅银生1，2，张文娟3，张君1，王智1. 黄连水煎剂漱口对固定正畸患者牙龈炎症的影响[J]. 山东大学学报(医学版), 2009, 47(11): 111-113.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed