SLC11A1、SGPP2基因多态性与山东汉族类风湿关节炎的关联性

山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (06): 89-93.

SLC11A1、SGPP2基因多态性与山东汉族类风湿关节炎的关联性

于成成1，李璐2，户中丹1，张源潮1，杨清锐1

1.山东大学附属省立医院风湿免疫科，济南 250000；
2.枣庄市立医院风湿免疫科，山东枣庄 277101

收稿日期:2012-02-22 出版日期:2013-06-10 发布日期:2013-06-10
通讯作者: 杨清锐, E-mail：qryang@163.com
基金资助:
国家自然基金面上项目(81172861)；山东省科技发展计划课题(2011GGH21829)。

Association between SLC11A1 and SGPP2 genes polymorphisms and rheumatoid arthritis in Han population of Shandong province

YU Cheng-cheng1， LI Lu2， HU Zhong-dan1， ZHANG Yuan-chao1, YANG Qing-rui1

1. Department of Rheumatology， Provincial Hospital Affiliated to Shandong University， Jinan 250000， China;
2. Department of Rheumatology, Zaozhuang Municipal Hospital， Zaozhuang 277101, Shandong, China

Received:2012-02-22 Online:2013-06-10 Published:2013-06-10

摘要/Abstract

摘要：

目的探讨SLC11A1和SGPP2基因的单核苷酸多态性(SNPs)与山东汉族人群类风湿关节炎(RA)的关联。方法采用Realtime PCR法对山东汉族134例RA患者(RA组)和242例健康者(对照组)SLC11A1基因的rs1059823、rs2695343位点和SGPP2的rs13382934、rs2009150位点及进行检测，采用SPSS13.0软件对其分析，数据分析采用χ2检验和Fisher确切概率法。结果 RA组SLC11A1基因的rs1059823、rs2695343位点及SGPP2的rs13382934、rs2009150位点与对照组相比差异无统计学意义(P>0.05)。结论 SLC11A1和SGPP2基因与山东汉族人群RA的易感性无关。

关键词: 关节炎，类风湿；单核苷酸；汉族；SLC11A1；SGPP2

Abstract:

Objective To detect SLC11A1 and SGPP2 genes single nucleotide polymorphism in Han population, and to analyze its association with increased risk of rheumatoid arthritis (RA) in Han people． Methods The study group was comprised with 134 Han RA patients and the control group consisted of 242 healthy Han subjects． Two SNPs of SCL11A1 and two SNPs of SGPP2 were detected and the results were analyzed by SPSS13.0 software． Fishers exact test and 2 test were used for statistical analysis． Results There was no significant difference (P>0.05) of rs1059823 and rs2695343 in SCL11A1 between Han RA group and the control group and no significant difference (P>0.05) of rs13382934 and rs2009150 in SGPP2 between Han RA group and the control group. Conclusion SCL11A1 and SGPP2 may not be the susceptibility genes of RA in Han population of Shandong Province．

Key words: Arthritis， rheumatoid； Single nucleotide； Han population； SLC11A1； SGPP2

中图分类号:

R593.24

于成成1，李璐2，户中丹1，张源潮1，杨清锐1. SLC11A1、SGPP2基因多态性与山东汉族类风湿关节炎的关联性[J]. 山东大学学报(医学版), 2013, 51(06): 89-93.

YU Cheng-cheng1， LI Lu2， HU Zhong-dan1， ZHANG Yuan-chao1, YANG Qing-rui1. Association between SLC11A1 and SGPP2 genes polymorphisms and rheumatoid arthritis in Han population of Shandong province[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(06): 89-93.

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