正常妊娠不同时期胎盘组织中chemerin的表达

山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (06): 81-83.

正常妊娠不同时期胎盘组织中chemerin的表达

张艳慧1，马玉燕1，杨宁2，张匀2，菅凤1，王琳琳1,刘振平2

山东大学齐鲁医院1.妇产科；2.基因室济南 250012

收稿日期:2012-12-06 出版日期:2013-06-10 发布日期:2013-06-10
通讯作者: 马玉燕, E-mail：yuyanma@sina.com
基金资助:
国家自然科学基金（81070504）。

Expression of chemerin in placentas at different stages of normal gestation

ZHANG Yan-hui1， MA Yu-yan1， YANG Ning2， ZHANG Yun2，JIAN Feng1， WANG Lin-lin1, LIU Zhen-ping2

1. Department of Obstetrics and gynecology; 2. Department of Genetics,
Qilu Hospital of Shandong University, Jinan 250012, China

Received:2012-12-06 Online:2013-06-10 Published:2013-06-10

摘要/Abstract

摘要：

目的探讨正常妊娠不同时期胎盘组织中chemerin水平变化，及其与妊娠进展的关系。方法选取妊娠早期孕妇20例，妊娠中期孕妇15例，妊娠晚期孕妇30例，采用免疫组织化学技术和实时定量PCR技术检测各妊娠组胎盘绒毛组织中chemerin水平。结果 chemerin阳性染色颗粒主要表达于胎盘组织中的合体滋养细胞及细胞滋养层细胞胞质中，各期均有不同程度的表达，妊娠晚期近临产组chemerin表达水平与早、中期妊娠组相比明显升高，差异具有统计学意义（P＜0.05）。结论 chemerin可能在维持妊娠期间母胎免疫应答中起重要的作用。

关键词: Chemerin；妊娠；免疫应答；母胎代谢;胎盘

Abstract:

Objective To investigate the expression of chemerin in human placentas at different stages of normal gestation and its relationship with gestation. Methods The chemerin expression in the placentas on first trimester（n=20）, second trimester (n=15) and third trimester (n=30) of normal pregnancy was determined by Real-time PCR and immuohistochimistry. Results Chemerin expression was observed in placentas during pregnancy，and was found in the cell cytoplasm of syncytiotrophoblast and cytotrophoblast. The expression of chemerin in placentas during second trimester of pregnancy was significantly higher (P<0.05). Conclusion Chemerin may play an important role in regulating maternal-fetal immune response during pregnancy.

Key words: Chemerin; Pregnancy; Immune response; Maternalfetal metabolism; Placenta

中图分类号:

R714.1

张艳慧1，马玉燕1，杨宁2，张匀2，菅凤1，王琳琳1,刘振平2. 正常妊娠不同时期胎盘组织中chemerin的表达[J]. 山东大学学报(医学版), 2013, 51(06): 81-83.

ZHANG Yan-hui1， MA Yu-yan1， YANG Ning2， ZHANG Yun2，JIAN Feng1， WANG Lin-lin1, LIU Zhen-ping2. Expression of chemerin in placentas at different stages of normal gestation[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(06): 81-83.

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