多囊卵巢综合征患者白细胞计数的变化特点

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (7): 78-80.

多囊卵巢综合征患者白细胞计数的变化特点

郑荣华，石玉华，盛燕，高芹，高选，陈子江

山东大学附属省立医院生殖医学中心，国家辅助生殖与优生工程技术研究中心，生殖内分泌教育部重点实验室，
山东省生殖医学重点实验室，济南 250021

收稿日期:2011-10-20 出版日期:2012-07-10 发布日期:2012-07-10
通讯作者: 陈子江(1959- )，女，教授，博士生导师，主要从事妇产科和生殖医学研究。 E-mail:chenzijiang@hotmail.com
作者简介:郑荣华(1985- )，女，硕士研究生，主要从事妇科和生殖医学研究。 E-mail: zhengrhua1@163.com
基金资助:
国家自然科学基金(81070461/H0404)；国家重点基础研究发展计划(973计划)(2011CB944502；2012 CB944700)

Changing Characteristics of peripheral white blood cell counts in patients with polycystic ovary syndrome

ZHENG Rong-hua, SHI Yu-hua, SHENG Yan, GAO Qin, GAO Xuan, CHEN Zi-Jiang

Center for Reproductive Medicine of Provincial Hospital Affiliated to Shandong University, National Research Center for
Assisted Reproductive Technology and Reproductive Genetics, The Key laboratory for Reproductive Endocrinology of
Ministry of Education, Shandong Provincial Key Laboratory of
Reproductive Medicine, Jinan, 250021, China

Received:2011-10-20 Online:2012-07-10 Published:2012-07-10

摘要/Abstract

摘要：

目的探讨多囊卵巢综合征(PCOS)患者外周血白细胞(WBC)计数与体质量指数(BMI)、总睾酮(T)、雌二醇(E2)和促黄体生成素(LH)的关系。方法对1016例PCOS患者(PCOS组)和1016例正常女性(对照组)的人体测量研究结果和基础内分泌指标进行回顾性分析，比较两组外周血WBC总数及其分类中性粒细胞(N)和淋巴细胞(L)计数，并分析PCOS患者外周血WBC总数及其分类N、L计数与BMI、T、E2、LH的相关性。结果 PCOS患者的外周血WBC总数和L计数明显高于正常女性(P<0.05)，WBC总数和L计数的升高与PCOS患者的BMI增加有关，与高水平E2和高水平LH不相关(P＞0.05)，WBC总数的升高与T呈正相关性(r=0.073,P<0.05)，L计数的升高与T不相关(P＞0.05)。结论 PCOS患者的WBC总数和淋巴细胞计数明显高于正常女性。

关键词: 多囊卵巢综合征；体质量指数；白细胞；淋巴细胞；总睾酮

Abstract:

Objective To assess the relationships between body mass index(BMI), total testosterone(T), estradiol (E2), luteinizing hormone (LH) and peripheral white blood cell (WBC) count in patients with polycystic ovary syndrome(PCOS). Methods 1016 women with PCOS and 1016 agematched healthy women participated in this study． Total WBC, neutrophil (N) and lymphocyte (L) count in the two groups were compared, and the correlation of BMI, T, E2, LH and total WBC, N, L count were analyzed in the PCOS group. Results Total WBC and L count increased significantly in the PCOS group compared to the control group (P<0.05). The increases of total WBC and L were correlated to BMI, but not correlated to E2(P＞0.05) or LH(P＞0.05). However, the increase of total WBC was positive correlated to T(r=0.073, P<0.05), and the increase of L was not correlated to T(P＞0.05). Conclusion Total WBC and L count in the PCOS group increase significantly compared to the control group.

Key words: Polycystic ovary syndrome; Body mass index; Peripheral white blood cell; Lymphocyte; Total testosterone

中图分类号:

R711.6

郑荣华，石玉华，盛燕，高芹，高选，陈子江. 多囊卵巢综合征患者白细胞计数的变化特点[J]. 山东大学学报(医学版), 2012, 50(7): 78-80.

ZHENG Rong-hua, SHI Yu-hua, SHENG Yan, GAO Qin, GAO Xuan, CHEN Zi-Jiang . Changing Characteristics of peripheral white blood cell counts in patients with polycystic ovary syndrome[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(7): 78-80.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

[1]	哈灵侠1,2, 石玉华1, 赵君利2, 陈子江1. 宁夏地区多囊卵巢综合征患者不同雄激素状态脂代谢特点的比较性分析[J]. 山东大学学报(医学版), 2013, 51(9): 88-91.
[2]	王玮1,滑天2,曹金凤1,崔娜1,杨爱敏1,姜蕾1,郝桂敏1. 来曲唑在多囊卵巢综合征促排卵中的应用[J]. 山东大学学报(医学版), 2013, 51(06): 25-28.
[3]	杨慧军1, 李媛1, 吴克良1, 李梅1, 车詈2, 马水英1, 仲万霞1, 陈子江1. 授精后5h补救性卵胞浆内单精子显微注射的临床应用价值[J]. 山东大学学报(医学版), 2011, 49(10): 139-142.