关键词: 结直肠肿瘤; p27蛋白 ; cyclinD1蛋白; 免疫组织化学；临床病理学；预后

Abstract:

Objective   To explore the expressions of p27 and cyclinD1 and to assess their prognostic values in the colorectal carcinoma.  Methods   The expressions of p27 and cyclinD1 in colorectal carcinoma tissues from 61 patients were examined by immunohistochemistry. The correlations between the expressions of p27 and cyclinD1 and clinicopathological parameters were evaluated.  Results   The positive expression rates of p27 and cyclinD1 were 72.13% and 45.90% in the colorectal carcinoma tissues. p27 expression was negatively correlated with the degrees of differentiation,  lymph node metastasis and clinical stage. The 5-year survival rate in the p27 negative group(38.24％)was lower compared with the p27 positive group (81.64%). The cyclinD1 expression was positively associated with the degrees of differentiation, lymph node metastasis, clinical stage and invasion depth. The 5-year survival rates in the cyclinD1 negative group(78.46％)were higher compared with the cyclinD1 positive group (59.63%). p27 was negatively correlated with cyclinD1.  Conclusion   The loss of p27 and over-expression of cyclinD1 are strongly associated with poor 5-year survival rate, which indicates that p27 and cyclinD1 might be taken as prognostic markers for the colorectal carcinoma.