阿尔茨海默病患者血糖、胰岛素及胰岛素降解酶水平的研究

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (3): 75-.

阿尔茨海默病患者血糖、胰岛素及胰岛素降解酶水平的研究

陈敏，单培彦，刘爱芬，麻琳，于晓琳

山东大学齐鲁医院干部保健科，济南 250012

收稿日期:2011-12-09 出版日期:2012-03-10 发布日期:2012-03-10
通讯作者: 单培彦(1957- )，女，主任医师，教授，主要从事老年性痴呆防治的研究。 E-mail：shanpy57@163.com
作者简介:陈敏(1982- )，女，硕士研究生，主要从事老年性痴呆防治的研究。

Plasma fasting glucose, fasting insulin and insulin degrading
enzyme levels in Alzheimer′s disease

CHEN Min, SHAN Pei-yan, LIU Ai-fen, MA Lin, YU Xiao-lin

Department of Geriatrics, Qilu Hospital of Shandong University, Jinan 250012,China

Received:2011-12-09 Online:2012-03-10 Published:2012-03-10

摘要/Abstract

摘要：

目的探讨阿尔茨海默病与血糖、胰岛素及胰岛素降解酶的关系，为进一步防治阿尔茨海默病提供理论依据。方法选择32例阿尔茨海默病患者(实验组)和30例正常老年人(对照组)，进行简易智能状态检查量表(MMSE)及临床痴呆评定量表(CDR)评分，实验组按照CDR分为轻、中、重度组。采用酶联免疫吸附法和化学发光法分别检测其血清胰岛素降解酶(IDE) 和胰岛素水平并计算胰岛素抵抗指数。结果与对照组相比，实验组血清IDE水平下降(P＜0.05)。对照组中IDE水平与胰岛素、胰岛素抵抗指数之间有相关性，而实验组中无相关性。实验组空腹血糖与认知功能呈负相关(P＜0.05)。轻、中、重度组患者之间血清IDE水平无统计学差异。结论胰岛素降解酶水平的下降与阿尔茨海默病的发生有一定相关性，在阿尔茨海默病患者体内胰岛素降解酶对胰岛素及胰岛素抵抗的调节可能出现障碍。

关键词: 阿尔茨海默病；胰岛素；胰岛素溶酶

Abstract:

Objective To explore the association between diabetes-related factors (fasting glucose, fasting insulin and insulin degrading enzyme) and Alzheimer's disease (AD). Methods 32 patients with AD (the patient group) and 30 normal elderly subjects (the control group) were enrolled. Blood samples were used for determining serum fasting insulin (Fins) by chemiluminescence assay and insulin degrading enzyme (IDE) by enzyme linked immunosorbent assay. The two groups were all tested by the mini-mental state examination (MMSE) and clinical dementia rating (CDR). Results The serum IDE in the patient group declined compared with the control group(P＜0.05). There were positive correlations of fasting glucose (FPG) and Fins with IDE in the control group while no correlations in the patient group. The score of MMSE was negatively correlated with the FPG level in the patient group. And there were no significant differences among the patients in different stages. Conclusion The IDE level decreases in patients with AD and may influence the function of IDE to adjust the insulin and the insulin resistance, so IDE may play a role in AD.

Key words: Alzheimer disease; Insulin; Insulysin

中图分类号:

R749.16

陈敏，单培彦，刘爱芬，麻琳，于晓琳. 阿尔茨海默病患者血糖、胰岛素及胰岛素降解酶水平的研究[J]. 山东大学学报(医学版), 2012, 50(3): 75-.

CHEN Min, SHAN Pei-yan, LIU Ai-fen, MA Lin, YU Xiao-lin. Plasma fasting glucose, fasting insulin and insulin degrading
enzyme levels in Alzheimer′s disease[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(3): 75-.

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