脑白质疏松症患者认知功能水平与脑血流动力学的关系

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (2): 57-.

脑白质疏松症患者认知功能水平与脑血流动力学的关系

张英丽1，吉中国1，张英瑞2

1.山东大学附属省立医院保健神经科，济南 250021； 2.聊城市人民医院神经内科监护室，山东聊城 252000

收稿日期:2011-10-08 出版日期:2012-02-10 发布日期:2012-02-10
通讯作者: 吉中国(1954- ),男，主任医师，教授，主要从事脑血管病的病因、发病机制及老年神经病学研究。
作者简介:张英丽(1983- ),女，硕士研究生，主要从事脑小血管病的研究。

Relationship between the cognitive function level and cerebral
hemodynamics in patients with leukoaraiosis

ZHANG Yin-li1, Ji Zhong-guo1, ZHANG Ying-rui2

1. Department of Preventive Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021;
2. Neurology Intensive Care Unit, Liaocheng People′s Hospital, Liaocheng, Shandong 252000, China

Received:2011-10-08 Online:2012-02-10 Published:2012-02-10

摘要/Abstract

摘要：

目的探讨脑白质疏松症(LA)患者认知功能水平与脑血流动力学的关系。方法对90例LA患者进行颅脑MRI、神经心理学与TCD检查，根据评分将其分为3组：无认知功能障碍组、轻度认知功能障碍组和痴呆组。运用方差分析及相关分析来研究LA患者不同认知功能水平与大脑中动脉(MCA)搏动指数(PI)、平均血流速度(Vm)的关系。结果 PI在无认知功能障碍组、轻度认知功能障碍组和痴呆组之间差异具有统计学意义(P＜0.05)，且PI与LA患者的认知功能水平为正相关关系(r=0.688，P＜0.01)。Vm在三组患者之间差异无统计学意义(P＞0.05)。结论 LA患者认知功能水平与大脑中动脉PI有关，PI值越大，LA患者认知功能障碍程度越重。LA患者的认知功能水平与大脑中动脉Vm无明显相关关系。

关键词: 脑白质疏松症；认知功能；经颅多普勒；平均脑血流速度；搏动指数

Abstract:

Objective To investigate the relationship between the cognitive function level and cerebral hemodynamics in patients with leukoaraiosis. Methods Ninety patients with LA were subjected to cerebral MRI, neuropsychological and TCD examinations. On the basis of neuropsychological scoring these patients were divided into three groups: without cognitive dysfunction, mild cognitive impairment and dementia. Pulsatility index (PI) and mean blood flow velocity (Vm) of middle cerebral artery (MCA) were studied using variance analysis and correlation analysis. Results PI Differences PI amongthe three groups were significant (P＜0.05)，and there was a positive correlation between PI and cognitive function level (r=0.688，P<0.01). By contrast, Vm differences among the three groups were not significant (P＞0.05). Conclusion The level of cognitive function in LA patients and their PI are related, and the greater the PI, the more severe the cognitive impairment. On the other hand, the level of cognitive function in LA patientswas not correlated with the Vm values.

Key words: Leukoaraiosis; Cognitive function; Transcranial Doppler; Mean flow velocity; Pulsatility index

中图分类号:

R743.9

张英丽1，吉中国1，张英瑞2. 脑白质疏松症患者认知功能水平与脑血流动力学的关系[J]. 山东大学学报(医学版), 2012, 50(2): 57-.

ZHANG Yin-li1, Ji Zhong-guo1, ZHANG Ying-rui2. Relationship between the cognitive function level and cerebral
hemodynamics in patients with leukoaraiosis[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(2): 57-.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

[1]	宓丹1，2，马贤德3，王建4. 眼针对局灶性脑缺血再灌注大鼠VEGF/VEGFR系统表达的影响[J]. 山东大学学报(医学版), 2013, 51(2): 22-.
[2]	王雪1,2,杨昆3,韩涛1,李文娜1,位坤坤1,刘奇迹2,刘学伍1. 杂合子导致CADASIL病患者家系NOTCH3基因突变[J]. 山东大学学报(医学版), 2012, 50(9): 63-.
[3]	纪孝伟1,2，毕建忠1. 卒中后抑郁大鼠脑内FGF-2表达的研究[J]. 山东大学学报(医学版), 2011, 49(9): 30-.