冠心病与谷胱甘肽过氧化物酶1基因Pro200Leu多态性

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (2): 152-.

冠心病与谷胱甘肽过氧化物酶1基因Pro200Leu多态性

杜训波1,刘同涛2,田昌伟1,房盛夏1,贾崇奇1

1.山东大学公共卫生学院流行病与卫生统计学研究所，济南 250012；
2.山东大学齐鲁医院心内科，济南 250012

收稿日期:2011-10-25 出版日期:2012-02-10 发布日期:2012-02-10
通讯作者: 贾崇奇(1961- )，男，教授，博士，主要从事心血管疾病流行病学的研究。 E-mail:jiachongqi@sdu.edu.cn
作者简介:杜训波(1986- )，男，硕士研究生，主要从事心血管疾病流行病学的研究。
基金资助:
山东省自然科学基金资助项目(Y2007C005)

Association of GPX1 gene Pro200Leu polymorphism with
coronary artery disease

DU Xun-bo1, LIU Tong-tao2, TIAN Chang-wei1, FANG Sheng-xia1, JIA Chong-qi1

1. Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan 250012, China；
2. Department of Cardiology, Qilu Hospital, Shandong University, Jinan 250012, China

Received:2011-10-25 Online:2012-02-10 Published:2012-02-10

摘要/Abstract

摘要：

目的探讨GPX1基因Pro200Leu多态性与冠心病的关系。方法采用病例对照研究方法，收集早发冠心病患者375例，迟发冠心病患者519例，对照334人，采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)基因分型技术对GPX1基因Pro200Leu多态性进行检测，采用logistic回归计算Pro200Leu多态性与冠心病风险的比值比(OR值)和95%可信区间(CI)。结果与对照组相比，早发冠心病组携带CT+TT基因型的个体比携带CC基因型更容易患冠心病，多因素调整后，OR=1.96(95%CI=1.17-3.31)；迟发冠心病组与对照组相比较，多因素调整后则无统计学意义(OR=1.75，95%CI=0.76-4.02)。结论 GPX1基因Pro200Leu多态性T等位基因可能是早发冠心病的一个危险因素。

关键词: 冠心病；GPX1基因；多态性；氧化应激

Abstract:

Objective To investigate the relationship between GPX1 gene Pro200Leu polymorphism and coronary artery disease (CAD). Methods A hospital-based case-control study was conducted on 375 premature CAD, 519 late-onset CAD patients and 334 controls with polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) to detect the polymorphism. Logistic regression models were performed to estimate the odds ratios (ORs) with 95% confidence intervals (CIs). Results The odds ratio of CT+TT versus CC genotype of Pro200Leu polymorphisms with CAD between early-onset CAD group and controls was statistically significant in multiple logistic model (OR: 1.96, 95%CI: 1.17-3.31). For the comparison between late-onset CAD group and controls, the odds ratio became nonsignificant after adjusting the potential confounders (OR: 1.75, 95%CI: 0.76-4.02). Conclusion T allele of GPX1 gene Pro200Leu polymorphism may be a risk factor in early-onset CAD.

Key words: Coronary artery disease; Glutathione peroxidase 1 gene; Polymorphism; Oxidative stress

中图分类号:

R181.23

杜训波1,刘同涛2,田昌伟1,房盛夏1,贾崇奇1. 冠心病与谷胱甘肽过氧化物酶1基因Pro200Leu多态性[J]. 山东大学学报(医学版), 2012, 50(2): 152-.

DU Xun-bo1, LIU Tong-tao2, TIAN Chang-wei1, FANG Sheng-xia1, JIA Chong-qi1. Association of GPX1 gene Pro200Leu polymorphism with
coronary artery disease[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(2): 152-.

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