活化诱导胞嘧啶核苷脱氨酶在肠型胃癌组织中的表达及与幽门螺杆菌感染的关系

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (12): 61-.

活化诱导胞嘧啶核苷脱氨酶在肠型胃癌组织中的表达及与幽门螺杆菌感染的关系

张琪1，2，李延青1，张翠萍2，赵坤2，孙向红3

1.山东大学齐鲁医院消化内科，济南 250012； 2.青岛大学医学院附属医院消化内科，山东青岛 266003；
3.青岛大学医学院附属医院药剂科，山东青岛 266003

收稿日期:2012-02-22 出版日期:2012-12-10 发布日期:2012-12-25
通讯作者: 李延青(1964- )，男，教授，博士生导师，主要从事功能性胃肠病和胰腺疾病领域研究。 E-mail:liyanqing@sdu.edu.cn
作者简介:张琪(1970- )，女，副主任医师，副教授，主要从事胃肠道肿瘤早期诊治的研究。 E-mail:cl_qdsjy@126.com

Expression of activation induced cytidine deaminase and its
relationship with helicobacter pylori in the development
of intestinal-type gastric cancer

ZHANG Qi1,2, LI Yan-qing1, ZHANG Cui-ping2, ZHAO Kun2, SUN Xiang-hong3

1. Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, China;
2. Department of Gastroenterology， Affiliated Hospital of Medical College， Qingdao University，
Qingdao 266003, Shandong, China; 3. Department of Pharmacy， Affiliated Hospital of Medical College，
Qingdao University， Qingdao 266003， Shandong, China

Received:2012-02-22 Online:2012-12-10 Published:2012-12-25

摘要/Abstract

摘要：

目的检测活化诱导胞嘧啶核苷脱氨酶(AID)蛋白在肠型胃癌发展过程中的表达及与幽门螺杆菌(H.pylori)感染的关系，探讨其在肠型胃癌发生中的作用及H.pylori的致癌机制。方法采用免疫组织化学方法分别检测了AID蛋白在H.pylori阳性及阴性浅表性胃炎、萎缩性胃炎肠化生和肠型胃癌中的表达情况，同时检测其与CDX2蛋白表达的相关性。结果 H.pylori阳性慢性浅表性胃炎、萎缩性胃炎肠化生、肠型胃癌组胃黏膜AID的表达率高于相应的H.pylori阴性组(P＜0.05), 萎缩性胃炎肠化生和肠型胃癌组胃黏膜AID的表达率高于慢性浅表性胃炎的表达率(P＜0.05)，萎缩性胃炎肠化生和肠型胃癌组AID的表达与CDX2表达均呈正相关(r=0.310, P＜0.05； r=0.324， P＜0.05)。结论 H.pylori慢性感染能导致胃黏膜上皮AID的异常表达，AID的异常表达可能参与了胃黏膜的肠化生及癌变。

关键词: 活化诱导胞嘧啶核苷脱氨酶；肠型胃癌；幽门螺杆菌；CDX2

Abstract:

Objective To investigate the expression of activation induced cytidine deaminase (AID) in the development of intestinal-type gastric cancer(IGC) and the relationship with H.pylori infection, and to investigate the role of AID and H.pylori in the carcinogenesis. Methods The expressions of AID in the chronic superficial gastritis (CSG),chronic atrophic gastritis (CAG) with intestinal metaplasia (IM) and intestinal-type gastric cancer(IGC) were detected with the immunohistochemical method, and H.pylori was detected. The relationship between AID and CDX2 was analyzed. Results The expression rates of AID in the H.pylori- positive groups were higher compared with the H.pylori-negative groups(P＜0.05). The expression rates of AID in CAG with IM and IGC were higher compared with CSG(P＜0.05). The expression of AID was positively correlated to the expressions of CDX2 in CAG with IM and IGC(r=0.310, P＜0.05； r=0.324， P＜0.05). Conclusion H.pylori may induce abnormal expression of AID in the gastric epithelia and AID may contribute to the development of IGC.

Key words: Activation induced cytidine deaminase; Gastric cancer; Helicobacter pylori; CDX2

中图分类号:

R573

张琪1，2，李延青1，张翠萍2，赵坤2，孙向红3. 活化诱导胞嘧啶核苷脱氨酶在肠型胃癌组织中的表达及与幽门螺杆菌感染的关系[J]. 山东大学学报(医学版), 2012, 50(12): 61-.

ZHANG Qi1,2, LI Yan-qing1, ZHANG Cui-ping2, ZHAO Kun2, SUN Xiang-hong3. Expression of activation induced cytidine deaminase and its
relationship with helicobacter pylori in the development
of intestinal-type gastric cancer[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(12): 61-.

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