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山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (1): 85-.

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人参皂苷Rg1和Rb1抗肝纤维化的体视学研究

董向前1，段丽平1，梁兵1，李树安1，柳波2，詹尔益2，
宋精玲3，杨志伟4，晋德光4，马岚青1   

  1. 昆明医学院 1.第一附属医院消化内科； 2.重点实验室； 3.电镜室； 4.第一附属医院中心实验室， 昆明 650032
  • 收稿日期:2011-09-01 出版日期:2012-01-10 发布日期:2012-01-10
  • 通讯作者: 马岚青(1974- )，女，博士，副主任医师，主要从事肝病基础及临床研究。 Email: malanqing@yahoo.com.cn
  • 作者简介:董向前(1980- )，男，硕士，住院医师，主要从事消化内科专业研究
  • 基金资助:

    昆明医学院青年基金(kylc200510)

A stereological study of Panax notoginseng saponin monomers Rg1 and Rb1 in inhibiting hepatic fibrosis

DONG Xiang-qian1, DUAN Li-ping1, LIANG Bing1, LI Shu-an1, LIU Bo2,
 ZHAN Er-yi2, SONG Jing-ling3, YANG Zhi-wei4, JIN De-guang4, MA Lan-qing1   

  1. 1. Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical College;
    2. The Key Laboratory, Kunming Medical College;  3. The Electron Microscope Laboratory, Kunming Medical College;
    4. The Central Laboratory, The First AffiliatedHospital of Kunming Medical College, Kunming, YunNan 650032, China
  • Received:2011-09-01 Online:2012-01-10 Published:2012-01-10

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摘要：

目的   观察三七总甙单体成分人参皂苷Rg1和Rb1对肝纤维化的作用。方法   用50%四氯化碳致大鼠肝纤维化模型,共35d，同时给予三七总皂甙单体成分人参皂苷Rg1或Rb1治疗，于第5周时分离肝组织，电镜观察肝组织病理变化，并应用体视学方法计量各组大鼠肝细胞线粒体的体积密度(Vvm)、面积密度(Svm)、比表面(Qm)和面数密度(Nam)。结果   人参皂苷Rg1及三七总甙能减轻肝组织胶原的沉积，改善肝纤维化程度，而人参皂苷Rb1不能改善肝纤维化程度；各组大鼠肝细胞线粒体体视学结果比较组间存在差异。结论   人参皂苷Rg1具有三七总甙的抗肝纤维化作用，在一些方面甚至超过三七总甙，故可以认为是较理想的防治肝纤维化的药物。人参皂苷Rb1不具有抗肝纤维化的作用，不是三七总甙抗肝纤维化的有效成分。 

关键词: 肝纤维化；三七总甙；人参皂苷Rg1；人参皂苷Rb1；体视学

Abstract:

Objective   To investigate the effect of Panax notoginseng saponin monomers Rg1 an Rb1  in inhibiting hepatic fibrosis. Methods   A rat model of hepatic fibrosis was established by using 50% CCl4.   Rg1 or Rb1 was administered by hypodermical injection. At the end of the treatment, pathological changes of hepatic tissues were observed by transmission electron microscope. Stereological data of liver cell mitochondria among all groups were collected and analyzed. Results   Rg1 and Panax notoginsenosides alleviated deposition of collagen in hepatic tissues and improved hepatic fibrosis, while Rb1 did not exhibit these functions. The stereological data of liver cell mitochondria among all the groups were statistically different.  Conclusion   Rg1 had antifibrosis effects, and Rg1 was more effective  than  Panax notoginsenosides in some aspects. Rg1 is the antifibrotic agent among the panaxsaponins.

Key words: Hepatic fibrosis; Panax Notoginsenosides; Panaxsaponin Rg1; Panaxsaponin Rb1; stereology

中图分类号: 

  • R575.2
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