关键词: 血脂异常；微量元素；主成分分析

Abstract:

Objective   To investigate the imbalance features of 6 trace elements (Zn, Se, Mn, Fe, Cu and Cr) in the serum of middle-aged and elder people with dyslipidemias, and to analyze connections between such imbalance and dyslipidemias. Methods   Patients with dyslipidemias were selected from the middle-aged and elderly population in 4 districts of Jinan, and those with cardiac cerebral and vascular diseases, diabetes mellitus or hereditary dyslipidemias were excluded. 137 patients were involved in the case group, and 119 healthy residents were randomly selected from the same population as the control group. With principal component analysis (PCA), 6 trace elements in the serum of all the subjects were comprehensively evaluated. Results   The first 4 principal components, whose accumulated contribution rates were all more than 75%, were extracted, and their function formulas were established. After that, the relation between the 4 principal components and their original variables was analyzed. The 4 principal components represented Se and Mn, Fe, Zn, and Fe and Cu, respectively. Conclusion   The content of Zn in the serum of middleaged and elder people with dyslipidmias tends to significantly decrease, and that of Se has a tendency to remarkably increase. Contents of Cu  and Cr are relatively insufficient. There is no apparent relevance between the content of Mn and dyslipidemias. An excess or lack of Fe are related to dyslipidemias. 

Key words: Dyslipidemias; Trace elements; Principal component analysis