关键词: 中重度牙周炎；牙周临床指标；龈沟液；骨钙素；电化学发光

Abstract:

Objective   To monitor the periodontal status during the initial stage of orthodontic therapy in moderate to severe periodontal patients by detection of periodontal clinical parameters in the initial stage of orthodontic therapy and osteocalcin level in the GCF after the first stress application. Methods   15 patients , with moderate to severe periodontitis, were selected as experimental group. The PLI、BI and PD were examined by electrochemical luminescence at pretreatment, 1st month and 2nd month after the treatment respectively, while OC level in GCF were examined before orthodontic treatment, 1, 24, 48, and 168 hours after the first stress application. The indices of control group, formed by 15 orthodontic patients who had healthy periodontal status, were compared. Results   After the periodontal treatment, the periodontal clinical levels of experimental group were lower than pre-treatment levels (P<0.05), while those after orthodontic treatment were not significantly different from before (P>0.05). The level of OC in the experimental group after the first stress application was significantly higher than that after the orthodontic, (P<0.05), and peaked at 24th hour, but went down to the pre-treatment levels at 168th hour, which was the same as that of the control group .Conclusion   The integrated orthodontic and periodontal treatment can improve the periodontal status in moderate to severe periodontal patients. Osteocalcin should be involved in bone remodeling in earlier orthodontic treatment.

Key words: Moderate to severe periodontitis; Periodontal clinical parameters; Gingival crevicular fluid; Osteocalcin; Electrochemiluminescence