关键词: 髓母细胞瘤； 显微外科手术；改良手术

Abstract:

Obejective   To investigate the clinical features and outcomes of microsurgical management of medulloblastoma. Methods   This retrospective analysis of the clinical and follow-up involved 115 patients who received microsurgery. The clinical data included the location, resection rate, radiotherapy, chemotherapy, shunt operation and follow-up results of the tumor. The microsurgical techniques for medulloblastoma were discussed. Results   Among the 115 patients, 86 had total tumor resection, 19 had subtotal resection and 7 had partial resection.  3 patient died after the surgery. All cases were confirmed medulloblastoma pathologically. Patency of the midbrain aqueduct was achieved in all the cases. Hydrocephalus were found in 97 patients before the operation, and most cases recovered well after the operation, with only 25 patients who received ventriculoperitoneal shunt operation afterwards. 112 patients received follow-up survey. Conclusion   The total removal of tumor with the application of microscopic surgery , adequate early-term postoperative whole brain-posterior cerebral concave-spinal cord radiotherapy and chemotherapy can prolong the survival time of the patients. appropriate posterior concave bone reformation and the replacement of the bone can reduce the postoperative complications such as cerebrospinal fluid leakage after conventional open skull operation.

Key words: Medullublastoma；Microsurgery；Modified operation