维生素E对孕鼠及胎鼠脑组织受手机辐射影响的保护作用

山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (9): 33-.

维生素E对孕鼠及胎鼠脑组织受手机辐射影响的保护作用

张静1，张裕华2，姜荣平3，廉志顺1，王慧1，罗芮1，郭冬梅1，崔晞1

1. 山东大学公共卫生学院卫生检验研究所，济南 250012；
2. 山东大学附属千佛山医院放射科，济南 250014；3. 山东省化工研究院，济南 250014

收稿日期:2011-05-29 出版日期:2011-09-10 发布日期:2011-09-10
通讯作者: 崔晞(1955- )，男，教授,主要从事微量元素与健康关系的研究。E-mail: cuixi @sdu. edu. cn
作者简介:张静(1986- )，女，硕士研究生，主要从事微量元素与健康关系的研究。
基金资助:
山东省自然科学基金资助课题 (Y2007C086)

Protective effects of vitamin E against electromagnetic radiation from cell phones in pregnant and fetal rats′ brain tissues

ZHANG Jing1, ZHANG Yu-hua2, JIANG Rong-ping3, LIAN Zhi-shun1，
WANG Hui1， LUO Rui1， GUO Dong-mei1， CUI Xi1

1. Department of Chemical and Bacterial Detection, School of Public Health, Shandong University， Jinan 250012, China；
2. Department of Radiology, Qianfoshan Hospital Affiliated to Shandong University， Jinan 250014, China；
3. Shandong Province Academy of Chemical Technology， Jinan 250014, China

Received:2011-05-29 Online:2011-09-10 Published:2011-09-10

摘要/Abstract

摘要：

目的研究妊娠期补充维生素E对母鼠及胎鼠脑组织受手机辐射影响的保护作用。方法 40只受孕大鼠随机分为5组，自妊娠第1天起，维生素E低、中、高剂量组分别按5mg/kg、15mg/kg、30mg/kg的剂量补充，阴性对照组和阳性对照组灌服脱维生素E的花生油，同时给予1h/次、3次/d的手机辐射，连续辐射21d，分娩后测定母鼠及胎鼠脑组织总抗氧化能力(T-AOC)和ATP酶(Na+-K+ATP酶和Ca+-Mg+-ATP酶)的活力变化。结果阳性对照组T-AOC、Na+-K+-ATP酶、Ca+-Mg+-ATP酶活性均较阴性对照组下降(P<0.05)。与阳性对照组比较，维生素E各剂量组T-AOC含量升高，其中，母鼠维生素E中、高剂量组较阳性对照组升高，胎鼠维生素E低、中、高剂量组均高于阳性对照组(P<0.05)。母鼠维生素E各剂量组Na+-K+-ATP酶和Ca+-Mg+-ATP酶活力均高于阳性对照组，胎鼠维生素E中、高剂量组ATP酶活力较阳性对照组升高(P<0.05)。结论维生素E对受手机辐射影响的母鼠及胎鼠的抗氧化能力和能量代谢有一定的保护作用。

关键词: 维生素E；手机辐射；总抗氧化能力；ATP酶；大鼠，Wistar

Abstract:

Objective To investigate protective effects of maternal vitamin E supplement against electromagnetic radiation from cell phones in pregnant and fetal rats′ brain tissues. Methods 40 pregnant rats were randomly divided into five groups. Low, middle and high dosages of vitamin E groups were supplemented with 5mg/kg, 15mg/kg, and 30mg/kg of vitamin E, respectively. The negative control group and the positive control group were given peanut oil which had vitamin E removed. All groups were exposed to a certain intensity of cell phone radiation for 1 hour each time, 3 times per day for 21 days from the first day of pregnancy. Total anti-oxidant capacity(T-AOC) and ATP enzyme (Na+-K+-ATP enzyme and Ca+-Mg+-ATP enzyme) activities in pregnant and fetal rats′ brain tissues were determined after delivery. Results T-AOC, Na+-K+-ATP enzyme activity, and Ca+-Mg+-ATP enzyme activity were all significantly lower in the positive control group than in the negative control group(P<0.05). Compared with the positive control group, T-AOC of pregnant mice was significantly higher in middle and high dosages of vitamin E groups, and -AOC of fetal mice was significantly higher in all three different dosages of vitamin E groups (P<0.05). ATP enzyme activity in pregnant mice was significantly increased in the three dosages of vitamin E groups compared with the positive control group(P<0.05)，and that in fetal mice was higher in middle and high dosages of vitamin E groups than in the positive control group(P<0.05). Conclusion Vitamin E has a protective effect against damage to antioxidant capacity and energy metabolism induced by cell phone electromagnetic radiation in pregnant mice and fetal mice.

Key words: Vitamin E; Electromagnetic radiation from cell phones; Total anti-oxidant capacity; ATP enzyme; Rats, Wistar

中图分类号:

R144.1

张静1，张裕华2，姜荣平3，廉志顺1，王慧1，罗芮1，郭冬梅1，崔晞1. 维生素E对孕鼠及胎鼠脑组织受手机辐射影响的保护作用[J]. 山东大学学报(医学版), 2011, 49(9): 33-.

ZHANG Jing1, ZHANG Yu-hua2, JIANG Rong-ping3, LIAN Zhi-shun1，WANG Hui1， LUO Rui1， GUO Dong-mei1， CUI Xi1. Protective effects of vitamin E against electromagnetic radiation from cell phones in pregnant and fetal rats′ brain tissues[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(9): 33-.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

[1]	尹龙龙，尹美尚，张毅，安康，郭冬梅，崔晞. 维生素E和锌对手机通话孕鼠及子代免疫力的影响[J]. 山东大学学报(医学版), 2013, 51(8): 107-110.
[2]	张巍1，2，李士雪1，李连波2，于夕荣2. 医院PET-CT中心18F正电子放射性药物生产及使用中工作人员的辐射剂量监测[J]. 山东大学学报(医学版), 2012, 50(12): 126-129.