关键词: 卵巢肿瘤；多态性；孕激素受体；雄激素受体

Abstract:

 Objective   To study the correlation of genetic susceptibility to epithelial ovarian cancer with two single nucleotide polymorphisms (SNP), +331G/A(rs10895068) and PROGINS(rs1042838),  in the progesterone receptor (PR) gene, and two DNA short tandem repeat (STR) polymorphisms, CAG(GDB:185508) and GGN(GDB:197027), in the androgen receptor (AR) gene. Methods   Genotypes of 40 patients with epithelial ovarian cancer and 48 healthy controls were analyzed by the DNA sequencing method. The relationship of genotypes with the risk, stages, and grades of ovarian cancer were analyzed. Results   No polymorphisms at the position +331 or PROGINS were detected in ovarian cancer patients and healthy controls, only GG type at the position +331 and CC type in PROGINS. There was no significant difference in CAG or GGN repeats of AR between the two groups, while the short set of GGN repeats increased the risk of ovarian cancer by 2.82 times (P<0.05). Neither differentiations nor stages of ovarian cancer were associated with the distribution of STR (P>0.05). Conclusion   GGN repeat polymorphism of the AR gene is related to the occurrence of epithelial ovarian cancer, and may be one of the main pathogenic factors.

Key words: Ovarian neoplasms; Polymorphism; Progesterone receptor; Androgen receptor