二甲双胍对初发2型糖尿病患者同型半胱氨酸和颈动脉内膜厚度的影响

山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (7): 6-.

二甲双胍对初发2型糖尿病患者同型半胱氨酸和颈动脉内膜厚度的影响

米念荣1,孟超1,王淑芳2

山东大学 1.医学院, 济南 250012; 2.附属济南市中心医院内分泌科, 济南 250013

收稿日期:2011-01-18 出版日期:2011-07-10 发布日期:2011-07-10
通讯作者: 王淑芳(1966- ),女,主任医师,主要从事糖尿病及胰岛素抵抗方面的研究。 E-mail:wangshufang@medmail.com.cn
作者简介:米念荣(1983- ),女,硕士研究生,主要从事糖尿病与动脉硬化方面的研究。

The influence of metformin on HCY and IMT in newly diagnosed type 2 diabetes

MI Nian-rong1, MENG Chao1， WANG Shu-fang2

1. School of Medicine, Shandong University, Jinan 250012, China;
2. Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China

Received:2011-01-18 Online:2011-07-10 Published:2011-07-10

摘要/Abstract

摘要：

目的观察初发2型糖尿病患者(T2DM)二甲双胍治疗前后血浆同型半胱氨酸( Hcy)、颈动脉内膜中层厚度(IMT)的变化及其二者之间的关系。方法选择30例初发T2DM患者(T2DM组)与20例健康志愿者(正常对照组)，比较两组Hcy和IMT的差异。T2DM组患者在合理膳食和适当运动的同时加服二甲双胍1500mg/d,疗程为1年, 检测治疗前后Hcy和IMT的变化，利用多元线性回归分析二者之间变化关系。结果与正常对照组相比，T2DM组血浆Hcy浓度和IMT显著增高(P<0.01，P<0.05)，经二甲双胍治疗后,血浆Hcy浓度和IMT均显著降低(P均<0.05)，且IMT与血浆Hcy浓度呈正相关(P<0.01)。结论血浆Hcy和IMT在预测T2DM大血管并发症方面有重要的临床意义，对初发T2DM早期应用二甲双胍能延缓其大血管并发症的发生发展。

关键词: 二甲双胍；2型糖尿病；同型半胱氨酸；颈动脉内膜中层厚度

Abstract:

Objective To investigate the changes of HCY(homocysteine) and IMT(intimal medial thickness) in newly diagnosed patients with type 2 diabetes mellitus(T2DM)before and after metformin, treatment and to explore the relationship between HCY and IMT. Methods Thirty type 2 diabetic patients and twenty healthy subjects were recruited. The T2DM subjects were given 1500mg/d metformin for one year. Changes of plasma HCY and IMT were determined before and after metformin treatment. Multivariate linear regression analysis was also used to analyze the relationship between HCY and IMT. Results Compared with the controls, plasma HCY and IMT were significantly higher in T2DM(P<0.01， P<0.05). After one year of metformin treatment, HCY and IMT were significantly reduced in T2DM(P<0.05). Conclusions HCY and IMT are important predictive factors for macro-vascular complications. Metformin could attenuate the progression of macrovascular lesions in T2DM.

Key words: Metformin; Type 2 diabetes mellitus; Homocysteine; Carotid intimal medial thickness

中图分类号:

R587. 1

米念荣1,孟超1,王淑芳2. 二甲双胍对初发2型糖尿病患者同型半胱氨酸和颈动脉内膜厚度的影响[J]. 山东大学学报(医学版), 2011, 49(7): 6-.

MI Nian-rong1, MENG Chao1，WANG Shu-fang2. The influence of metformin on HCY and IMT in newly diagnosed type 2 diabetes[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(7): 6-.

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