关键词: 肺肿瘤;蛋白质P53;缺氧诱导因子-1α

Abstract:

Objective     To investigate different expressions and correlation of HIF-1α and P53 in bronchioloalveolar carcinoma(BAC) and lung adenocarcinoma with bronchioloalveolar features(ADWBF). Methods     Clinico-pathological factors and paraffin-embedded samples of BAC and ADWBF patients were collected. Clinical data were compared between the two groups.HIF-1α and P53 expressions were detected using the SP immunohistochemical method. Difference and correlation between HIF-1α and P53 expressions in the two groups were analyzed by χ2  test. Results     Statistical analysis showed a significant difference existed in gender and tumor size between BAC and ADWBF(P＜0.05). Positive rates of HIF-1α expression in the BAC group and ADWBF group were 25.0％(8/32) and 49.3％(34/69), respectively. Positive rates of P53 expression in the BAC group and ADWBF group were 6.3％(2/32) and 26.1％(18/69), respectively. There was a statistical difference in HIF-1α and P53 expressions between the two groups  (P＜0.05).There was a significant positive correlation between HIF-1α and P53 expressions(P＜0.05，rp＝0.338). Conclusion    HIF-1α and P53 synergistically play important roles in pathogenesis and progression of lung adenocarcinoma.

Key words:  Lung neoplasms; Protein P53; Hypoxia inducible factor-1α