三叶因子1、2和环氧合酶-2在胃癌组织中的表达

山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (4): 150-153.

三叶因子1、2和环氧合酶-2在胃癌组织中的表达

石磊1，赖铭裕1，梁志海2，刘诗权2，黄杰安2，唐国都2，姜海行2

广西医科大学第一附属医院 1.老年消化内科; 2.消化内科，南宁 530021

收稿日期:2010-10-19 出版日期:2011-04-10 发布日期:2011-04-10
通讯作者: 赖铭裕（1969- ），男，副教授，副主任医师，主要从事胃癌发病机制的研究。 E-mail: laimingyu2005103@yahoo.com.cn
作者简介:石磊（1983- ），男，硕士研究生，主要从事胃癌发病机制的研究。 E-mail:shileimonment@163.com
基金资助:
广西青年科学基金资助项目（桂科青0728075）；广西卫生厅自筹经费科研课题基金资助项目（桂卫Z2008111）。

Expressions of trefoil factors 1 and 2 and cyclooxygenase-2 in gastric carcinoma

SHI Lei1, LAI Ming-yu1, LIANG Zhi-hai2, LIU Shi-quan2, HUANG Jie-an2, TANG Guo-du2, JIANG Hai-xing2

1. Department of Geriatric Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;
2. Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

Received:2010-10-19 Online:2011-04-10 Published:2011-04-10

摘要/Abstract

摘要：

目的研究三叶因子1(TFF1)、三叶因子2(TFF2)和环氧合酶2(COX2)在正常胃黏膜组织、癌旁组织和胃癌组织中的表达情况，探讨TFF1、TFF2表达与胃癌发生的关系。方法采用SP免疫组化方法检测30例正常胃黏膜组织、50例癌旁组织和50例胃癌组织中TFF1、TFF2和COX-2的表达。结果在正常胃黏膜组织、癌旁组织和胃癌组织中，TFF1、TFF2表达呈逐渐减弱趋势(P<0.01)，而COX-2的表达呈逐渐上升趋势(P<0.01)，TFF1、TFF2的表达强度与后者呈负相关( P<0.01)。结论 COX-2的表达增加抑制TFF1、TFF2的表达，细胞增殖与凋亡失衡，最终导致胃癌的发生。

关键词: 三叶因子1；三叶因子2；环氧合酶-2；胃肿瘤；免疫组织化学

Abstract:

Objective To investigate expressions of trefoil factor 1 (TFF1) ,trefoil factor 2 (TFF2) and cyclooxygenase-2(COX-2) in the normal gastric mucosa, carcinoma-adjacent tissues and gastric carcinoma, and to explore their roles in pathogenesis of gastric carcinoma. Methods Expressions of TFF1,TFF2 and COX-2 were determined by immunohistochemistry in 130 gastric specimens, including 30 specimens of normal gastric mucosa, 50 specimens of carcinoma-adjacent tissues and 50 specimens of gastric carcinomas. Results In the normal gastric mucosa, carcinoma-adjacent tissues and gastric carcinoma, TFF1 and TFF2 expressions showed a decreasing tendency(P<0.01)), while the COX-2 expression showed an increasing tendency(P<0.01). Expressions of TFF1 and TFF2 were negatively related to that of COX2(P<0.01). Conclusion The increase in expression of COX-2 inhibits expressions of TFF1and TFF2, and unbalance between proliferation and apoptosis of cells results in carcinogenesis.

Key words: Trefoil factor 1; Trefoil factor 2; Cyclooxygenase-2; Gastric neoplasms; Immunohistochemistry

中图分类号:

R573.9

石磊1，赖铭裕1，梁志海2，刘诗权2，黄杰安2，唐国都2，姜海行2. 三叶因子1、2和环氧合酶-2在胃癌组织中的表达[J]. 山东大学学报(医学版), 2011, 49(4): 150-153.

SHI Lei1, LAI Ming-yu1, LIANG Zhi-hai2, LIU Shi-quan2, HUANG Jie-an2, TANG Guo-du2, JIANG Hai-xing2 . Expressions of trefoil factors 1 and 2 and cyclooxygenase-2 in gastric carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(4): 150-153.

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