肝癌衍生生长因子和微血管密度在人肝外胆管癌的表达及相关性研究

山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (4): 123-128.

肝癌衍生生长因子和微血管密度在人肝外胆管癌的表达及相关性研究

郭森1，刘炎锋1，赵锐1，崔夕军2，牛军1，陈雨信1，吴小鹏1，徐克森1

1．山东大学齐鲁医院肝胆外科，济南 250012；2．威海市文登中心医院普外一科，山东文登 264400

收稿日期:2011-03-04 出版日期:2011-04-10 发布日期:2011-04-10
通讯作者: 徐克森（1952- ），男，博导，主要从事消化道肿瘤的发病机制、治疗及肝胆疾病的研究。 E-mail: xukesen@163.com
作者简介:郭森（1980- ），男，博士研究生，主要从事消化道肿瘤的发病机制、治疗及肝胆外科疾病的研究。E-mail: guosen4321@163.com
基金资助:
山东大学研究生自主创新基金资助项目（yzc10131）。

Expressions and correlations of hepatoma-derived growth factor and microvascular density in human extra-hepatic cholangio-carcinoma

GUO Sen1, LIU Yan-feng1, ZHAO Rui1, CUI Xi-jun2, NIU Jun1,CHEN Yu-xin1, WU Xiao-peng1, XU Ke-sen1

1. Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, Jinan 250012, China;
2. First Department of General Surgery, Wendeng Central Hospital of Weihai, Wendeng 264400, Shandong, China

Received:2011-03-04 Online:2011-04-10 Published:2011-04-10

摘要/Abstract

摘要：

目的探讨肝癌衍生生长因子（HDGF）和微血管密度（MVD）在肝外胆管癌的表达及其与临床病理特征和预后的关系。方法采用链霉亲和素-过氧化物酶免疫组织化学法检测65例肝外胆管癌患者术后组织中HDGF和MVD的表达情况，分析其与临床病理特征以及患者预后的关系。结果免疫组化结果显示，HDGF和MVD在胆管癌组织中的阳性表达率分别为46.2%和58.5%；Spearman等级相关分析显示，HDGF和MVD有正相关关系（r=0.279, P=0.024）；HDGF表达阳性患者的总生存率明显小于阴性患者的总生存率（23.3% vs 62.9%, P<0.001）;多因素分析结果表明HDGF是一个独立的预后因素。结论 HDGF在肝外胆管癌中表达与MVD相关，可作为一个独立的预后指标，HDGF可能通过促进新生血管形成，在肝外胆管癌的发生发展中起重要作用。

关键词: 肝癌衍生生长因子；微血管密度；肝外胆管癌；预后

Abstract:

Objective To investigate expressions of hepatoma-derived growth factor(HDGF) and micro-vascular density(MVD) and their correlations with clinicopathological characteristics and prognosis in patients with extrahepatic cholangio-carcinoma. Methods Expressions of HDGF and MVD were analyzed in 65 patients after surgery for extra-hepatic cholangio-carcinoma by immunohistochemistry using the avidin-biotin peroxidase complex method, and then their correlations with clinicopathological characteristics and survival time of patients were analyzed. ResultsImmunohistochemical results showed positive expression rates of HDGF and MVD were 46.2% and 58.5%, respectively. Spearman rank correlation analysis demonstrated HDGF and MVD expressions had a positive correlation(r=0.279,P=0.024). Survival analysis showed that the HDGF-positive group had a significantly poorer survival rate than the HDGF-negative group did (23.3% vs 62.9%, P<0.001). Multivariate analysis demonstrated that HDGF expression is an independent prognostic factor. Conclusions HDGF expression significantly correlates with MVD and is an independent prognostic factor for human extra-hepatic cholangio-carcinoma. HDGF plays an important role in promoting angiogenesis during the development of extrahepatic cholangio-carcinoma.

Key words: Hepatoma-derived growth factor； Microvascular density； Extrahepatic cholangiocarcinoma； Prognosis

中图分类号:

R735.8

郭森1，刘炎锋1，赵锐1，崔夕军2，牛军1，陈雨信1，吴小鹏1，徐克森1. 肝癌衍生生长因子和微血管密度在人肝外胆管癌的表达及相关性研究[J]. 山东大学学报(医学版), 2011, 49(4): 123-128.

GUO Sen1, LIU Yan-feng1, ZHAO Rui1, CUI Xi-jun2, NIU Jun1,CHEN Yu-xin1, WU Xiao-peng1, XU Ke-sen1. Expressions and correlations of hepatoma-derived growth factor and microvascular density in human extra-hepatic cholangio-carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(4): 123-128.

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