关键词: 心室颤动；模型，动物；心肺复苏；电除颤

Abstract:

Objective     To investigate effects of continuous and one-shock defibrillations on prolonged ventricular fibrillation (VF). Methods    VF was electrically induced in 24 dogs. After 8 min of untreated VF, the animals were randomly divided into the continuous shock group and the one-shock group. After continuous or one-shock defibrillation, the animals were given 2 min of cardiopulmonary resuscitation (CPR). The process of rescue continued until the animals attained return of spontaneous circulation (ROSC) or it lasted for 15min. Time of CPR interruptions, rates of ROSC, hemodynamic variables and the left ventricular ejection fraction (LVEF) were recorded. Results    Compared with the continuous shock group, animals in the oneshock group had significantly shorter time of CPR interruptions (P<0.05)， improved rate of ROSC (P<0.05), and higher coronary perfusion pressure and LVEF（both P<0.05）. Conclusion    The effect of one-shock defibrillation on prolonged VF is significantly better than that of continuous shock defibrillation.

Key words: Ventricular fibrillation; Model, animal; Cardiopulmonary resuscitation; Defibrillation