关键词: 川续断；牙周病；釉基质蛋白；牙移动；破骨细胞

Abstract:

Objective   To observe the effects of the traditional Chinese drug Dipsacus Asper Wall on the construction of new periodontal tissue， as well as the mechanism of osteoclast during orthodontic tooth movement in rats. Methods   Forty-eight female 8-week-old SPF SD rats were selected. They were randomly divided into 2 groups: the Dipsacus Asper Wall group and control group. Severe periodontal disease models were established and enamel matrix protein was used for periodontal reconstruction.  Then, the model for orthodontic tooth movement was established. 3 mL of NS was drenched to the control group and the Dipsacus Asper Wall group was given 6g/kg per day Dipsacus Asper Wall decoction.  The rats were executed 28 days later. Rat upper jaws were separated. The distances of the tooth movement were measured and slices from the periodontium of the maxillary first molars were observed under an optical microscope. Results   The movement distance of the first molar was significantly larger in the Dipsacus Asper Wall group than that in the control group. The amount of osteoclast in Dipsacus Asper Wall group was significantly larger than that in the control group (P<0.05). Conclusions   Dipsacus Asper Wall is useful for the proliferation and differentiation of the osteoclast in regenerated periodontal, and can promote regenerated alveolar bone resorption and restoration in orthodontictooth movement.

Key words: Dipsacus asper wall; Periodontal disease; Enamel matrix protein; Orthodontic tooth movement; Osteoclast