舌鳞癌组织中半乳糖凝集素-1的表达及其与临床病理因素的相关性研究

山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (11): 138-.

舌鳞癌组织中半乳糖凝集素-1的表达及其与临床病理因素的相关性研究

张东1，何海贤2，董立新3，陈正岗4，王玉敏1，刘少华1

1. 山东大学齐鲁医院口腔科，济南 250012； 2. 济南军区司令部机关医院，济南 250001；
3. 日照市中医院口腔科，山东日照 276800； 4. 青岛市立医院口腔科，山东青岛 266071

收稿日期:2011-05-31 出版日期:2011-11-10 发布日期:2011-11-10
通讯作者: 刘少华（1964- ），男，博士，教授，硕士生导师,主要从事口腔颌面外科疾病的临床及基础研究。E-mail:lshabccba@126.com
作者简介:张东（1978- ），男，医学博士，主治医师，主要从事口腔颌面部肿瘤的分子生物学机制研究。
基金资助:
山东省自然科学基金资助项目（ZR2010HQ064）;山东大学自主创新基金资助项目（2010TS094）;济南市高校院所自主创新计划资助项目（201004054）

Expression of Galectin-1 in squamous cell carcinoma of the tongue and correlation with clinicopathological parameters

ZHANG Dong1, HE Hai-xian2, DONG Li-xin3, CHEN Zheng-gang4, WANG Yu-min1, LIU Shao-hua1

1. Department of Oral and Maxillofacial Surgery, Qilu Hospital Shandong University, Jinan 250012, China;
2. Subsidiary Hospital of the Headquarters of Jinan Military Area Command of Chinese PLA, Jinan 250001, China;
3. Department of Oral Medicine, Rizhao Hospital of TCM, Rizhao 276800, Shandong, China;
4. Department of Oral and Maxillofacial Surgery, Qingdao Municipal Hospital, Qingdao University,
Qingdao 266071, Shandong, China

Received:2011-05-31 Online:2011-11-10 Published:2011-11-10

摘要/Abstract

摘要：

目的研究舌鳞状细胞癌（TSCC）组织中半乳糖凝集素-1（Gal-1）的表达及意义。方法对36例TSCC患者石蜡标本切片进行免疫组织化学染色，研究Gal-1的表达特点并结合临床资料探讨其与临床病理因素的关系。结果 Gal-1在TSCC组织中高表达，免疫组织化学染色主要定位于肿瘤及周围基质细胞胞浆；Gal-1的表达与肿瘤分化程度、区域淋巴结转移及肿瘤组织淋巴细胞浸润程度等因素相关。结论 Gal-1在TSCC发生发展及侵袭转移中具有重要作用，可望成为舌癌诊断和治疗的新靶点。

关键词: 舌鳞状细胞癌；半乳糖凝集素-1；免疫组织化学；淋巴结转移；淋巴细胞浸润

Abstract:

Objective To investigate expression of Gal-1 in squamous cell carcinoma of the tongue (TSCC), and correlation with clinicopathological parameters. Methods 36 paraffin embedded specimens of TSCC were probed with Gal-1 antibody by the immunohistochemistrical method. The relationship between Gal-1 expression and clinicopathological parameters was analyzed. Results Overexpression was found in cancer cells. The positive reaction was predominately located in the cytoplasm. Tumor differentiation, lymph node metastasis and the degree of lymphocyte infiltration showed a statistically significant correlation with Gal-1 expression. Conclusion Gal-1 expression correlates to the progression of squamous cell carcinoma, and may play an important role in tumor cell invasion and metastasis. Gal-1 might be used as a new biomarker in diagnosis and a target for cancer therapy.

Key words: Squamous cell carcinoma of tongue; Galectin-1; Immunohistochemistry; Lymph nodes metastasis; Lymphocyte infiltration

中图分类号:

R739.8

张东1，何海贤2，董立新3，陈正岗4，王玉敏1，刘少华1. 舌鳞癌组织中半乳糖凝集素-1的表达及其与临床病理因素的相关性研究[J]. 山东大学学报(医学版), 2011, 49(11): 138-.

ZHANG Dong1, HE Hai-xian2, DONG Li-xin3, CHEN Zhenggang4, WANG Yu-min1, LIU Shao-hua1. Expression of Galectin-1 in squamous cell carcinoma of the tongue and correlation with clinicopathological parameters[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(11): 138-.

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