Fibroscan在乙肝相关肝纤维化诊断中的临床应用研究

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (9): 93-96.

Fibroscan在乙肝相关肝纤维化诊断中的临床应用研究

单容1，王爱光2

1.济南市传染病医院特检科，济南 250021； 2.山东大学附属千佛山医院海扶中心，济南 250014

收稿日期:2010-07-22 出版日期:2010-09-16 发布日期:2010-09-16
作者简介:单容（1973- ），女，硕士研究生，主要从事肝脏疾病诊断方面研究。 E-mail:shanrong@126.com

Fibroscan in the diagnosis of hepatitis B related fibrosis

SHAN Rong1, WANG Ai-guang2

1. Department of Special Clinical Laboratory, Jinan Infectious Disease Hospital, Jinan 250021, China;
2. HIFU Center, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, China

Received:2010-07-22 Online:2010-09-16 Published:2010-09-16

摘要/Abstract

摘要：

目的探讨Fibroscan(FS)在乙肝相关肝纤维化诊断中的临床应用价值。方法对已进行肝活检的59例乙肝患者测定其硬度（stiffness）值，同时进行血清纤维化四项透明质酸（HA）、层粘连蛋白（LN）、三型前胶原（PⅢP）、四型胶原（CV-IV）的检测，应用受试者工作特征（ROC）曲线分析方法，以肝活检病理学结果为金标准对FS及血清纤维化四项临床价值进行分析。结果随着肝纤维化程度的提高，stiffness值有显著升高，与病理学结果存在良好的相关性,r=0.76（P=0.00），ROC曲线分析stiffness、 HA 、LN 、PⅢP、CVIV曲线下面积分别为0.98、0.82、0.74、0.59、0.76，FS灵敏度及特异度均高于血清纤维化四项检测。结论 FS是乙肝相关肝纤维化诊断中非常有效的一种检查手段。

关键词: 肝弹性成像；肝纤维化；肝硬化；肝炎，乙型，慢性

Abstract:

Objective To investigate the clinical value of fibroscan (FS) in the diagnosis of hepatitis B related fibrosis. Methods Stiffness, hyaluronic acid(HA), laminin(LN), propeptide type Ⅲ of procollagen (PⅢP) and collagen Type Ⅳ(CV-IV) were detected in 59 chronic hepatitis B patients having undergone liver biopsy. The diagnostic values of FS and serum liver fibrosis markers were tested by the receiver operating characteristic (ROC) curve, using liver biopsy as the gold standard. Results In patients with moderate or serious fibrosis, the stiffness value was significantly high, and correlated with the fibrosis degree （r=0.76, P=0.00）.The ROC curve analysis showed that the areas under the curve for stiffness, HA, LN, PⅢP and CV-IV were 0.98, 0.82, 0.74, 0.59 and 0.76 respectively. The sensitivity and specificity for stiffness were higher than those with serum liver fibrosis markers. Conclusion FS is an effective method in the diagnosis of hepatitis B related fibrosis.

Key words: Liver elastography； Liver fibrosis； Liver cirrhosis； Hepatitis B, chronic

中图分类号:

R575.2

单容1，王爱光2. Fibroscan在乙肝相关肝纤维化诊断中的临床应用研究[J]. 山东大学学报(医学版), 2010, 48(9): 93-96.

SHAN Rong1, WANG Ai-guang2. Fibroscan in the diagnosis of hepatitis B related fibrosis[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(9): 93-96.

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