关键词: 脂联素；高血压；胰岛素抵抗

Abstract:

Objective  To investigate the adiponectinemia in hypertension patients is the result of an increase in blood pressure itself or the accompanying condition of insulin resistance(IR), study the role in the onset and development of hypertension, then provide the basis for the prevention and treatment of hypertension and metabolic syndrome. Methods   Forty seven essential hypertensive patients without IR, 41 normotensive subjects with IR，41 essential hypertensive patients with IR and 41 normotensive subjects without IR were enrolled in our research. We used analysis of covariance to compare the plasma adiponectin concentrations among the four groups in order to approach the association of adiponectin concentration with hypertension and IR. Results   There was no significant difference of adiponectin concentration among the four groups(P>0.05); adiponectin concentrations in normotensive subjects without IR male group(4.757mg/L) were significantly higher than that of the other three groups, which were 3.070mg/L, 2.964mg/L, 2.604mg/L(P=0.000; P=0.001; P=0.002). No interaction was detected significantly between the insulin resistance and hypertension to adiponectin concentration. Conclusion   There is a gender difference in serum adiponectin levels; Insulin resistance and hypertension were independent factors for adiponectinemia in the male subjects.

Key words: Adiponectin; Hypertension; Insulin resistance