两种剂量肾上腺素在家猪长时程室颤心肺复苏中的疗效比较

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (4): 32-35.

两种剂量肾上腺素在家猪长时程室颤心肺复苏中的疗效比较

孟祥林,钟敬泉,苏国英,曾绮娴,刘红臻,刘东林,王远龙,李景莎,张运

山东大学齐鲁医院心内科，济南 250012

收稿日期:2009-10-12 出版日期:2010-04-16 发布日期:2010-04-16
通讯作者: 钟敬泉（1963- ），男，主任医师，博导，主要从事心脏电生理和心功能的基础和临床研究。 Email：zwky1668@vip.sina.com
作者简介:孟祥林（1983- ），男，硕士研究生，主要从事室颤心肺复苏的研究。
基金资助:
国家自然科学基金项目（30871039）；教育部留学回国人员科研启动基金资助项目（26010105450804）

Comparison of the effects of two doses of epinephrine during cardiopulmonary resuscitation in a swine model of prolonged ventricular fibrillation

MENG Xianglin, ZHONG Jingquan, SU Guoying, ZENG Qixian, LIU Hongzhen， LIU Donglin, WANG Yuanlong, LI Jingsha, ZHANG Yun

Department of Cardiology，Qilu Hospital of Shandong University， Jinan 250012， China

Received:2009-10-12 Online:2010-04-16 Published:2010-04-16

摘要/Abstract

摘要：

目的比较两种剂量肾上腺素在长时程室颤家猪心肺复苏中的疗效。方法将16头家猪随机分为两组，分别为标准剂量肾上腺组（0.02mg/kg），大剂量肾上腺组（0.1mg/kg）。采用体外电击法制备室颤动物模型，并于8min室颤后依次给予2min心肺复苏，除颤，肾上腺素。观察血流动力学和自主循环恢复情况。结果自主循环恢复率两组一样, 两组间血流动力学和除颤成功率差异无统计学意义。结论大剂量肾上腺素没有改善血流动力学，也没有提高除颤成功率和自主循环恢复率。

关键词: 肾上腺素；长时程室颤；心肺复苏

Abstract:

Objective To compare the effects of two doses of epinephrine in a swine model of pronged ventricular fibrillation. Methods Sixteen domestic swine were randomly divided into two groups and received a standard dose of epinephrine (Sepi-gro, 0.02mg/kg) or a high dose of epinephrine (Hepi-gro, 0.1mg/kg) . Ventricular fibrillation (VF) was electrically induced and sustained for eight minutes. Then 2 minutes of cardiopulmonary resuscitation, shock and epinephrine were successively given. Hemodynamics and restoration of spontaneous circulation（ROSC) were observed. Results ROSC rates were identical in both groups. Hemodynamics and successful defibrillation rate had no significant differences between the two groups. Conclusion A high dose of Epinephrine does not i
mprove hemodynamics, ROSC rate and successful defibrillation rate.

Key words: Epinephrine; Prolonged ventricular fibrillation; Cardiopulmonary resuscitation

中图分类号:

R605.97

孟祥林,钟敬泉,苏国英,曾绮娴,刘红臻,刘东林,王远龙,李景莎,张运. 两种剂量肾上腺素在家猪长时程室颤心肺复苏中的疗效比较[J]. 山东大学学报(医学版), 2010, 48(4): 32-35.

MENG Xianglin, ZHONG Jingquan, SU Guoying, ZENG Qixian, LIU Hongzhen，LIU Donglin, WANG Yuanlong, LI Jingsha, ZHANG Yun . Comparison of the effects of two doses of epinephrine during cardiopulmonary resuscitation in a swine model of prolonged ventricular fibrillation[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(4): 32-35.

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