关键词: 氯诺昔康；非甾体类抗炎药；固体脂质纳米粒；溶剂扩散法

Abstract:

Objective  To develop solid lipid nanoparticles of lornoxicam(Lnxc-SLNs) and evaluate their physicochemical properties． Methods  Based on the singlefactor experiment, lornoxicam loaded SLNs were prepared with the solvent diffusion method by orthogonal experiment design. Their morphology was investigated by transmission electron microscopy (TEM). Zeta potential and particle size were evaluated by laser scatter. Entrapment efficiency and drug loading were determined. The in vitro release behavior was investigated with the film dynamic dialyzed method. Results  The optimal formula was obtained by an orthogonal design: the ratio  of drug and lipid was 1∶10, the ratio of glyceryl monostearate and soybean phospholipid was 1.5∶1, 1.2% poloxamer 188 and 0.4% between 80 were used as the surface acting agent, the ratio of oil phase and aqueous phase was 1∶5. The obtained SLNs were spherical, and mean size and Zeta potential of SLNs were 185.3nm and (-27.65±0.91) mV. Entrapment efficiency of lornoxicam in SLNs was (86.24±3.39) % and (8.62±0.34) % for drug loading. The in vitro release behavior conformed to bio-exponential kinetics. Conclusion　SLNs provide a good sustained-release effect in vitro and may be a promising carrier for intravenous delivery of non-steroid anti-inflammatory drugs（NSAIDs）.

Key words: Lornoxicam; Non-steroid anti-inflammatory drug; Solid lipid nanoparticles; Solvent diffusion method