颅内肿瘤危险因素的病例对照研究

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (4): 147-150.

颅内肿瘤危险因素的病例对照研究

吴敏1，李刚2，孙金龙3，江玉泉2，王洁贞4

山东大学 1. 公共卫生学院社会医学与卫生事业管理学研究所，济南 250012；
2. 齐鲁医院神经外科，济南 250012； 3. 第二医院神经外科，济南 250033；
4. 公共卫生学院流行病与卫生统计学研究所，济南 250012

收稿日期:2009-12-18 出版日期:2010-04-16 发布日期:2010-04-16
通讯作者: 王洁贞(1943- )，女，教授，博士生导师，主要从事医学统计学理论及应用研究。 Email: wjzh2097@126.com
作者简介:吴敏(1980- )，女，博士研究生，主要从事慢性病管理及卫生服务研究。

A case-control study on risk factors of intracranial tumors

WU Min1， LI Gang2, SUN Jinlong3, JIANG Yuquan2, WANG Jiezhen4

1. Institute of Social Medicine and Health Administration, School of Public Health, Shandong University, Jinan 250012, China;
2. Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan 250012, China;
3. Department of Neurosurgery, Second Hospital of Shandong University, Jinan 250033, China;
4. Institute of Epidemiology and Health Statistics, Shandong University, Jinan 250012, China

Received:2009-12-18 Online:2010-04-16 Published:2010-04-16

摘要/Abstract

摘要：

目的探讨颅内肿瘤的危险因素和保护因素。方法采用成组设计病例对照研究方法，对264例原发性颅内肿瘤患者和273例对照进行问卷调查，应用非条件Logistic回归模型推断暴露因素与颅内肿瘤的关系。结果单因素和多因素Logistic回归分析结果表明，源于配偶的被动吸烟、源于同事的被动吸烟、职业性接触汽（柴）油和经常接触农药可增加患颅内肿瘤的危险性，其OR值及95%CI分别为1.777(1.103,2.861)、1.911(1.095,3.334)、4.298(1.008,18.314)和1.728(1.000,3.049)。饮酒和啤酒酒精摄入量＜9mL/d可降低患颅内肿瘤的危险性，其OR值及95%CI分别为0.297(0.108,0.821)和0.216(0.046,1.024)。结论颅内肿瘤的危险因素为源于配偶及同事的被动吸烟、职业性接触汽（柴）油和经常接触农药；保护因素为饮酒和啤酒酒精摄入量＜9mL/d。

关键词: 颅内肿瘤；危险因素；病例对照研究

Abstract:

Objective To analyze the relationship between exposures and intracranial tumors. Methods A hospital-based case-control study including 264 cases of intracranial tumors and 273 controls was carried out and logistic regression model was used to explore the potential risk factors of intracranial tumors. Results According to univariate and multivariate logistic regression models, passive smoking from spouse and colleagues, occupational touching gasoline or diesel fuel, and using an insecticide usually increased the risk of intracranial tumors, while alcohol consumption and beer alcohol consumption less than 9mL/d decreased the risk. The OR and 95% CI of these factors were 1.777(1.103,2.861),1.911(1.095,3.334),4.298(1.008,18.314),1.728(1.000,3.049), 0.297(0.108,0.821) and 0.216(0.046,1.024). Conclusion Risk factors of intracranial tumors are passive smoking from spouse and colleague, touching gasoline, diesel fuel and insecticides, and protective factors are alcohol consumption and beer alcohol consumption less than 9mL/d.

Key words: Intracranial tumor; Risk factor; Casecontrol study

中图分类号:

R739.41

吴敏1，李刚2，孙金龙3，江玉泉2，王洁贞4. 颅内肿瘤危险因素的病例对照研究[J]. 山东大学学报(医学版), 2010, 48(4): 147-150.

WU Min1， LI Gang2, SUN Jinlong3, JIANG Yuquan2, WANG Jiezhen4. A case-control study on risk factors of intracranial tumors[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(4): 147-150.

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