YH-16对三维适形放疗的肿瘤患者血压和凝血及纤溶系统功能的影响

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (3): 131-.

YH-16对三维适形放疗的肿瘤患者血压和凝血及纤溶系统功能的影响

王阳1，胡立宽1，王娇1，王翠红1，张勇2

山东大学 1. 齐鲁医院放疗科，济南 250012; 2. 附属千佛山医院药剂科，济南 250014

收稿日期:2009-10-26 出版日期:2010-03-16 发布日期:2010-03-16
通讯作者: 胡立宽（1956- ），男，教授，博士生导师，主要从事肿瘤放射增敏研究。
作者简介:王阳（1984- ），男，硕士研究生，主要从事肿瘤血管靶向药物药物治疗的研究。
基金资助:
山东省卫生厅资助课题（2003HZ083）

Effect of YH-16 on blood pressure, coagulation and fibrinolytic-function of malignant tumors treated with three-dimensional conformal radiotherapy

WANY Yang1，HU Likuan1，WANY Jiao1，WANY Cuihong1,ZHANG Yong2

1. Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012, China;
2. Department of Pharmaceutical Preparation, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, China

Received:2009-10-26 Online:2010-03-16 Published:2010-03-16

摘要/Abstract

摘要：

目的观察三维适形放疗的肿瘤患者接受重组人血管内皮抑制素（YH-16），其血压、凝血、纤溶系统相关指标的变化，探讨YH16在联合三维适形放疗时可能导致高血压、出血、血栓等不良反应。方法 30例患者随机分为两组，对照组（n=15）接受三维适形放疗，用药组（n=15）接受三维适形放疗的同时，每日静脉YH16 15mg滴注，连续14d。YH16使用前1d及使用后3、7、14d空腹采集外周静脉血，用全自动血凝仪检测凝血酶原时间(P T)、纤维蛋白原（Fib）、部分凝血活酶时间(APTT )、凝血酶时间( TT )和D二聚体（D-D）。两组患者在治疗前及治疗过程中每2d早晚各测2次血压。结果用药组患者的TT和Fib在7、14d时较对照组患者差异有统计学意义（P＜0.05），其他检查指标两组患者差异无统计学意义（P＞0.05），两组患者血压无明显变化（P＞0.05）。结论 YH-16对于肿瘤患者凝血功能具有一定影响。

关键词: 重组人血管内皮抑制素；恶性肿瘤；放射治疗；血压；血液凝固；纤溶

Abstract:

Objective To observe the changes of blood pressure, coagulation and fibrinolytic function of malignant tumor treated with YH-16 united with 3DCRT, and discuss the possibility of hypertension, hemorrhage and thromboembolism caused by YH-16. Methods 30 patients were randomly divided into two groups. The control group (15 patients) received 3DCRT, and the YH-16 group (15 patients) was treated with YH-16 15mg, iv drip, d1～14 when receiving 3DCRT. Serum PT, APTT, Fib, and D-dimer were measured with an automatic coagulometer on d 0, 3, 7, 14 when YH16 was used. Blood pressure was measured twice in the morning and evening every other day during the treatment. Results PT and FIb of the YH-16 group on d7, 14 but not APTT, TT, D-dimer, blood pressure, significantly changed in relation to those of the control group. Conclusion YH-16 impacts the coagulation function of malignant tumor patients.

Key words: Recombinant human endostatin; Malignant tumors; Radiotherapy; Blood pressure; Blood coagulation; Fibrinolysis

中图分类号:

R730.58

王阳1，胡立宽1，王娇1，王翠红1，张勇2. YH-16对三维适形放疗的肿瘤患者血压和凝血及纤溶系统功能的影响[J]. 山东大学学报(医学版), 2010, 48(3): 131-.

WANY Yang1，HU Likuan1，WANY Jiao1，WANY Cuihong1,ZHANG Yong2. Effect of YH-16 on blood pressure, coagulation and fibrinolytic-function of malignant tumors treated with three-dimensional conformal radiotherapy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(3): 131-.

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