关键词: 肝炎病毒，丙型；核糖核酸，丙型肝炎病毒；基因型

Abstract:

Objective   To explore the distribution and related factors of hepatitis C virus (HCV) genotypes.  Methods  HCV genotypes were detected using gene chip assay in 448 patients who were infected with HCV.  HCV RNA levels were quantified by real-time PCR in 388/448 patients. The correlation between HCV genotypes and each variable (including gender,  age, the HCV level) was analyzed. Results    4 HCV genotypes (1a, 1b, 2a and 3b) and 4 mixed genotypes (1b+2a，1a+1b，1a+1b+2a，1b+3b) were found; of these 1b and 2a were the more common genotypes,  accounting for 61.2% and 32.8% respectively.  Logistic regression analysis indicated that genotype 1b independently correlated with high serum HCV RNA level.  Conclusion   HCV genotype 1b predominates in patients with HCV infection in the Shandong area,  correlating with high serum HCV RNA level.

Key words: Hepatitis C virus;   Hepatitis C virus RNA;  Genotype