2型糖尿病正常糖耐量一级亲属抗氧化能力的研究

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (2): 10-13.

2型糖尿病正常糖耐量一级亲属抗氧化能力的研究

刘新凤1,魏凌云1,王平1,王霞2

1. 山东省泰山慢性病医院内分泌科, 山东泰安 271000;
2. 山东大学齐鲁医院内分泌科, 济南 250012

收稿日期:2009-11-20 出版日期:2010-02-16 发布日期:2010-02-16
作者简介:刘新凤(1970- ),女,主治医师,主要从事糖尿病的糖脂代谢研究。

Antioxidant capacity in patients with type 2 diabetes and their first-degree relatives with normal glucose tolerance

LIU Xinfeng1, WEI Lingyun1, WANG Ping1, WANG Xia2

1. Department of Endocrinology, Shandong Taishan Chronic Hospital, Tai′an 271000, Shandong China;
2. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China

Received:2009-11-20 Online:2010-02-16 Published:2010-02-16

摘要/Abstract

摘要：

目的观察2型糖尿病患者及其正常糖耐量一级亲属抗氧化能力的改变。方法随机选取58例2型糖尿病患者作为糖尿病组;72例上述患者正常糖耐量一级亲属作为观察组;年龄、性别和体质量指数匹配、无糖尿病家族史的35例健康志愿者作为对照组。比较各组的超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、谷胱甘肽过氧化物酶(GSH-PX)、总抗氧化能力(T-AOS)的改变。结果与对照组相比,糖尿病组SOD、 NO、GSH-PX和T-AOS明显降低(P<0、05),MDA明显升高(P<0、05)。观察组的SOD有降低趋势(P=0、058),MDA有升高趋势(P=0、052),NO、GSHPX、T、AOS 无明显变化。结论 2型糖尿病患者抗氧化能力明显降低,其正常糖耐量一级亲属抗氧化能力亦有降低趋势。

关键词: 糖尿病;非胰岛素依赖型;一级亲属;抗氧化能力

Abstract:

Objective To investigate the changes of antioxidant ability in patients with type 2 diabetes mellitus and their normoglycemic first-degree relatives. Methods 58 patients with type 2 diabetes mellitus were selected as the diabetes group, 72 normoglycemic first-degree relatives as the observation group, and 35 healthy controls without a diabetic family history matched for age, sex and body mass index as the control group. Changes of superoxide dismutase (SOD), maleic dialdehyde(MDA), nitric oxide(NO), glutathione peroxidase(GSH-PX) and total antioxidant status(T-AOS) were compared. Results SOD, NO, GSH-PX and T-AOS were significantly lower (P<0、05) and MDA was higher (P<0、05) in the diabetic group compared with those in the control group; SOD showed an increasing trend (P=0、058) and MDA showed a decreasing trend (P=0、052) in the observation group. But NO, GSH、PX and T、AOS had no significant changes. Conclusions Antioxidant ability significantly declines in patients with type 2 diabetes mellitus, and also shows a declining trend in their normoglycemic first-degree relatives.

Key words: Diabetes mellitus, non-insullin dependent;First-degree relatives;Antioxidant ability

中图分类号:

R578、1

刘新凤1,魏凌云1,王平1,王霞2. 2型糖尿病正常糖耐量一级亲属抗氧化能力的研究[J]. 山东大学学报(医学版), 2010, 48(2): 10-13.

LIU Xinfeng1, WEI Lingyun1, WANG Ping1, WANG Xia2. Antioxidant capacity in patients with type 2 diabetes and their first-degree relatives with normal glucose tolerance[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(2): 10-13.

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