在线尿素清除率监测估算终末期肾病患者血液透析尿素清除指数的研究

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (12): 94-.

在线尿素清除率监测估算终末期肾病患者血液透析尿素清除指数的研究

隋准，王梅

北京大学人民医院肾内科，北京100044

收稿日期:2010-10-20 发布日期:2010-12-16
作者简介:隋准 (1979 ), 男，主治医师，博士研究生，主要从事慢性肾脏病及血液净化的研究。 Email ：suizhun@bjmu.edu.cn

Estimation of dialysis dose (Kt／V Urea) by online clearance monitoring in hemodialysis patients with end stage of renal disease

SUI Zhun, WANG Mei

Department of Nephrology, The People′s Hospital of Beijing University, Beijing 100044， China

Received:2010-10-20 Published:2010-12-16

摘要/Abstract

摘要：

目的探讨在线尿素清除率监测值与取血法检测尿素清除指数(Kt／V)之间的关系，并建立由在线尿素清除率推导Kt／V的计算公式。方法测定74例稳定血液透析患者的在线尿素清除率监测值与取血法Kt／V值。首先通过相关分析得出在线尿素清除率监测值与取血法Kt／V值的相关性，然后通过临床参数的多因素线性回归分析得出各临床参数之间的比例关系，根据这种比例关系建立由在线尿素清除率推导Kt／V的计算公式。结果在线尿素清除率监测的Kt/V值比传统取血法计算的spKt/V值低，直线相关分析显示，二者具有良好的相关性（r=0.690，P<0.001），通过建立影响Kt／V值临床参数的回归方程，在线尿素清除率的计算可以推导出Kt／V值。结论在线尿素清除率监测值与取血法Kt／V之间存在较高的相关性，可应用在线尿素清除率监测值估算取血法Kt／V值。

关键词: 血液透析；充分性；在线尿素清除率监测

Abstract:

Objective To investigate the relationship between dialysis dose measured by online clearance monitoring (OCM) and Kt／V Urea from pre-and post-dialysis blood-urea samples, and set up a prediction rule to estimate spKt/V by OCM. Methods OCM and Kt／V Urea data from 74 hemodialysis patients were measured. The relationship between OCM and Kt／V Urea was analyzed by correlation assay. Clinical parameters were put into the linear regression formula, based on which the prediction rule was calculated to estimate Kt／V Urea by OCM. Results Dialysis dose measured by OCM was lower than Kt／V Urea, and they had close relationship（r=0.690，P<0.001）. Based on clinical parameters, Kt／V Urea could be calculated by OCM. Conclusion There is close relationship between OCM and Kt／V Urea. And based on clinical characters, Kt／V Urea could be calculated by OCM.

Key words: Hemodialysis; Adequacy; Online clearance monitoring

中图分类号:

R692.5

隋准，王梅. 在线尿素清除率监测估算终末期肾病患者血液透析尿素清除指数的研究[J]. 山东大学学报(医学版), 2010, 48(12): 94-.

SUI Zhun, WANG Mei. Estimation of dialysis dose (Kt／V Urea) by online clearance monitoring in hemodialysis patients with end stage of renal disease[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(12): 94-.

参考文献

相关文章 5

[1]	孔祥雷，宝群，魏勇，贾晓妍，陈萍，唐利军，王尊松，李文斌，崔美玉，许冬梅. 血液透析患者矿物质和骨代谢紊乱控制情况的单中心研究[J]. 山东大学学报(医学版), 2012, 50(8): 116-119.
[2]	. 冠状动脉介入诊疗术患者造影剂肾病的危险因素研究[J]. 山东大学学报(医学版), 2009, 47(10): 98-101.
[3]	. 持续非卧床腹膜透析患者大动脉僵硬度影响因素分析[J]. 山东大学学报(医学版), 2009, 47(10): 75-79.
[4]	. 益肾活血汤通过p38MAPK信号途径调控系膜细胞纤连蛋白及Ⅳ型胶原的研究[J]. 山东大学学报(医学版), 2009, 47(9): 66-69.
[5]	孔祥雷，唐利军，王尊松，李文斌，魏勇，贾晓妍，许冬梅. 维持性血液透析患者透析间期体重增长与动脉硬化的关系[J]. 山东大学学报(医学版), 2009, 47(11): 138-140.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed