复发性阿弗他溃疡患者止凝血系统的检测及意义

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (12): 86-89.

复发性阿弗他溃疡患者止凝血系统的检测及意义

商红1，朱媛媛2，王福芳1，戚向敏3

1．山东省心血管蛋白质组学重点实验室山东大学齐鲁医院干部保健科，济南 250012；
2.山东大学齐鲁医院血液病研究室，济南 250012； 3.山东大学口腔医院综合科，济南 250012

收稿日期:2010-10-26 发布日期:2010-12-16
通讯作者: 戚向敏（1963- ），女，教授，硕士生导师，研究方向为口腔粘膜病。 E-mail:xiangmin-qi@yahoo.com.cn
作者简介:商红（1966- ），女，主治医师，硕士，研究方向为口腔粘膜病。
基金资助:
山东省科技发展计划资助项目（2010G0020246）

Detection of coagulation and hemostasis and its significance in patients with recurrent aphthous ulcer

SHANG Hong1, ZHU Yuan-yuan2, WANG Fu-fang1, QI Xiang-min3

1. Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics,
Qilu Hospital of Shandong University, Jinan 250012, China；
2. Department of Haematology, Qilu Hospital of Shandong University, Jinan 250012, China；
3. Comprehensive Department, Stomatology Hospital of Shandong University, Jinan 250012, China

Received:2010-10-26 Published:2010-12-16

摘要/Abstract

摘要：

目的探讨复发性阿弗他溃疡（RAU）患者凝血、抗凝及纤溶指标的变化及临床意义。方法选取RAU患者58例，分为轻型阿弗他溃疡（MiAU）组、重型阿弗他溃疡（MjAU）组及疱疹样阿弗他溃疡（HU）组，以50例健康成人为对照组，采用ACL200型全自动凝血分析仪、酶联免疫吸附（ELISA）法检测血浆凝血因子VⅢ活性（FVⅢ:C）、蛋白C抗原（PC:Ag）、总蛋白S抗原（TPS:Ag）、组织型纤溶酶原激活物抗原（t-PA:Ag）、纤溶酶原激活剂抑制物1抗原（PAI-1:Ag）、D-二聚体（D-Dimer）含量。结果 RAU患者PC:Ag、TPS:Ag、PAI-1:Ag、D-Dimer含量均高于对照组（P均＜0.01），t-PA:Ag明显低于对照组（P＜0.01）。MjAU组PC:Ag低于MiAU组（P＜0.05）；MiAU组FVⅢ:C显著高于对照组（P＜0.01），而MjAU组FVⅢ:C虽高于对照组，但差异无统计学意义（P＞0.05）。结论 RAU患者体内存在凝血、抗凝及纤溶系统异常，而FVⅢ:C、PC:Ag水平与疾病的严重程度有关。

关键词: 复发性阿弗他溃疡；凝血系统；抗凝系统；纤溶系统

Abstract:

Objective To investigate the changes of coagulant and hemostatic parameters in patients with recurrent aphthous ulcer (RAU). Methods 58 patients with RAU and 50 healthy controls were recruited into the study. RAU patients were classified into three groups: the minor aphthous ulcers (MiAU) group, the major aphthous ulcers (MjAU) group and the herpetiform ulcers (HU) group. Factor VⅢ clotting activity (FVⅢ:C), protein C antigen (PC:Ag), total protein S antigen (TPS:Ag), tissue-type plasminogen activator antigen (tPA:Ag), plasminogen activator inhibitor-1 antigen (PAI-1:Ag) and D-dimer were detected by ELISA or by ACL-200 full automatic coagulation analyzer. Results PC:Ag, TPS:Ag, PAI-1:Ag and D-Dimer content were significantly higher in RAU patients than in controls (P＜0.01). The level of t-PA:Ag was significantly decreased in patients with RAU (P＜0.01). PC:Ag was lower in the MjAU group than in the MiAU group (P＜0.05). The lever of FVⅢ:C was significantly increased in MiAU patients compared with the controls (P＜0.01), while no statistical significance was observed between MjAU patients and controls (P＞0.05). Conclusion There were coagulant, anticoagulant and fibrinolytic abnormalities in patients with RAU, and the changes of FVⅢ:C and PC:Ag were correlated with the severity of RAU.

Key words: Recurrent aphthous ulcer; Coagulation; Anticoagulation; Fibrinolysis

中图分类号:

R781.5

商红1，朱媛媛2，王福芳1，戚向敏3. 复发性阿弗他溃疡患者止凝血系统的检测及意义[J]. 山东大学学报(医学版), 2010, 48(12): 86-89.

SHANG Hong1, ZHU Yuan-yuan2, WANG Fu-fang1, QI Xiang-min3. Detection of coagulation and hemostasis and its significance in patients with recurrent aphthous ulcer[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(12): 86-89.

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