关键词: 代谢综合征； 危险因子； 临床始动因子

Abstract:

Objective     To explore the clinical initiation factor of matebolic syndrome(MS). Methods      The subjects were selected from male workers on the job at the authorities in Dezhou who had a high prevalence rate of MS. The MS risk factors, such as increased waist circumference(WC≥90cm) and blood pressure (systolic blood pressure≥130mmHg or diastolic blood pressure ≥85mmHg), elevated levels of blood glucose and triglyceride (fasting glucose≥5.6mmol/L, triglyceride≥1.7mmol/L) and decreased level of high-density lipoprotein cholesterol (HDL-C＜1.03mmol/L), were investigated and analyzed among the subjects. All the subjects were divided into two groups: the obese group(WC≥90cm, n=370) and the non-obese group(WC＜90cm, n=228), and the prevalence of MS and characteristics of MS risk factors were compared between the two groups. 136 MS patients selected from the subjects were randomly divided into the diet-alone group (group A, n = 45), the exercise-alone group (group B, n=45) and the diet + exercise group (group C, n=46) for 3-month intervention. The intervention effects were compared and evaluated according to improvements of MS risk factors, oral glucose tolerance test (OGTT) and HOMA-IR among groups A, B and C. Group C, which had a better intervention effect, was divided into two groups according to the improvement of WC after 3-month intervention: group C1 (WC shortening ≥7cm, n=21) and group C2 (WC shortening＜7cm, n=25). Improvements of MS risk factors, OGTT and HOMA-IR were compared between groups C1 and C2. Results      MS prevalence of male workers on the job at the authorities was 41.3% in Dezhou. The prevalence of MS increased with age. Increased WC had a high prevalence (62%) and a positive-correlation with increased blood pressure and elevated triglyceride. Blood pressure, blood glucose and triglyceride levels were significantly higher in the obese group at every age stage than those in the non-obese group(P＜0.05). WC, blood pressure, triglyceride, HOMA-IR and OGTT were improved significantly in group C after intervention(P＜0.05). Subjects in group C1 were younger than in group C2(43±10.6 vs 48±9.7, P＜0.05) and blood pressure, triglyceride, HOMA-IR and OGTT in group C1 were significantly improved than those in group C2(P＜0.05). Conclusion     Increased WC is a clinical initiation factor of MS.  WC control and diet plus exercise intervention can effectively prevent and treat MS, and early intervention has a better effect.

Key words: Metabolic syndrome; Risk factor; Clinical initiation factor