关键词: 2型糖尿病；动脉粥样硬化；Apelin

Abstract:

Objective  To explore the relationship between serum Apelin levels and atherosclerosis in early type 2 diabetes. Methods  60 type 2 diabetes patients whose disease duration was less than 3 years were recruited. Their jugular artery,common iliac artery and femoral artery were examined using color Doppler ultrasonography.According to the results,the patients were divided into the non-plaque group and the plaque group. Thirty-two age and sex-matched healthy controls were enrolled. Besides routine biochemical examination，enzyme-like immunosorbent assaywas used to determine fasting serum Apelin levels of all the people. All the results were statistically analyzed. Results  Serum Apelin levels in the patients were significantly higher than those in the normal control group(P＜0.05);serum Apelin levels were significantly higher in the non-plaque group than those in the plaque group(P＜0. 05). Multiple stepwise regression analysis showed that the serum Apelin level was mainly influenced by the insulin resistance index and serum cholesterol level,　while logistic regression showed that the serum Apelin level may be a protective factor of atherosclerosis in early type 2 diabetes patients. Conclusion  In early type 2 diabetes,low serum Apelin level may be a predictor of atherosclerosis， and Apelin may be an inhibitory factor for atherosclerosis.

Key words: Type 2 diabetes mellitus; Atherosclerosis; Apelin