舍曲林辅助治疗伴有抑郁症状的青少年支气管哮喘的疗效观察

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (1): 109-112.

舍曲林辅助治疗伴有抑郁症状的青少年支气管哮喘的疗效观察

王金东1，焦志安2，赵国庆2，李荟1

1. 山东大学医学院，济南 250012； 2. 山东大学附属省立医院临床心理科，济南 250021

收稿日期:2009-08-20 出版日期:2010-01-16 发布日期:2010-01-16
通讯作者: 焦志安（1964- ），男，硕士生导师，副教授，主要从事心身疾病的研究。
作者简介:王金东（1981- ），男，硕士研究生，主要从事心身疾病的研究。 E-mail:335355571@qq.com

Curative effect of Zoloft for adjuvant treatment of teenagers′bronchial asthma accompanied by depression

WANG Jindong1,　JIAO Zhian2,　ZHAO Guoqing2,　LI Hui1

1. School of Medicine， Shandong University， Jinan 250012， China； 2. Department of Psychology， Shandong Provincial Hospital Affiliated to Shandong University， Jinan 250021， China

Received:2009-08-20 Online:2010-01-16 Published:2010-01-16

摘要/Abstract

摘要：

目的探讨舍曲林辅助治疗伴有抑郁症状的青少年支气管哮喘的疗效及安全性。方法将符合纳入标准的77例青少年支气管哮喘患者随机分为两组:治疗组40例，在常规治疗基础上加服舍曲林，对照组37例，加服安慰剂，疗程12周。治疗后的第6、12周末进行疗效及安全性评定。结果治疗12周后，治疗组抑郁治疗有效率（72.5%）及哮喘治疗有效率（95.0%）均优于对照组（分别为37.8%、72.9%），且差异有统计学意义（P＜0.05）。2组不良反应均较轻，SERS各因子发生率及总分比较差异均无统计学意义（P＞0.05）。结论舍曲林对治疗伴有抑郁症状的青少年支气管哮喘患者有效，且安全性好。

关键词: 舍曲林；青少年；支气管哮喘

Abstract:

Objective To explore the curative effect and the reliability of Sertraline for adjuvant treatment of teenagers′ bronchial asthma accompanied by depression. Methods A total of 77 patients meeting the inclusion standards were randomly divided into the treatment group (n=40) and the control group (n=37). Sertraline was added into the routine anti-depression and anti-asthmatic treatment in the treatment group, while a placebo was added in the control group. Then the curative and side effects in the all patients were assessed at the end of the 6th and 12th weeks after the initiation of the study. Results The total effective rate of anti-depression and anti-bronchial asthma in the treatment group was 75.0% and 95.0% respectively, and compared with 37.8% and 72.9% in the control group after3 months of the initiation of the study, and the differences were statistically significant(P＜0.05). The side effects in the two groups were slight, and the incidences of all the factors in SERS（rating scale or side effects） between the twogroups had no significant differences (P＞0.05). Conclusion Sertraline is effective and safe in adjuvant treatment of teenagers′ bronchial asthma accompanied by depression.

Key words: Sertraline; Teenager; Bronchial asthma

中图分类号:

R749

王金东1，焦志安2，赵国庆2，李荟1. 舍曲林辅助治疗伴有抑郁症状的青少年支气管哮喘的疗效观察[J]. 山东大学学报(医学版), 2010, 48(1): 109-112.

WANG Jindong1,　JIAO Zhian2,　ZHAO Guoqing2,　LI Hui1. Curative effect of Zoloft for adjuvant treatment of teenagers′bronchial asthma accompanied by depression[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(1): 109-112.

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