米非司酮对人早孕绒毛组织核转录因子-κB表达的影响

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (1): 106-.

米非司酮对人早孕绒毛组织核转录因子-κB表达的影响

郑晓静，孙颖，刘姝，赵兴波，李明江

山东大学附属省立医院妇产科，济南 250021

收稿日期:2009-08-25 出版日期:2010-01-16 发布日期:2010-01-16
通讯作者: 李明江(1963- )，男，主任医师，主要从事妇科肿瘤和内分泌的研究
作者简介:郑晓静(1983- )，女，硕士研究生，主要从事妇科肿瘤和内分泌的研究。
基金资助:
山东省自然科学基金资助课题(2004ZX04)；国家自然科学基金资助课题(30571960)

Effect of mifepristone on expression of nuclear factor-κB in human villi during early pregnancy

ZHENG Xiaojing， SUN Ying， LIU Shu， ZHAO Xingbo， LI Mingjiang

Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shangdong University, Jinan 250021, China

Received:2009-08-25 Online:2010-01-16 Published:2010-01-16

摘要/Abstract

摘要：

目的探讨米非司酮对人早孕绒毛组织中核转录因子-κB（NF-κB）表达的影响。方法人工流产组早孕绒毛18例和药物流产组早孕绒毛22例，应用逆转录聚合酶链反应（RT-PCR）和免疫组织化学技术分别测定两组早孕绒毛组织中NF-κB蛋白和mRNA的分布与含量。结果药物流产组早孕绒毛组织中NF-κB mRNA表达量与人工流产组相比下调明显（P＜0.01）；药物流产组早孕绒毛细胞滋养层细胞中NF-κB蛋白表达与人工流产组相比明显下调（P＜0.05）。结论米非司酮引起早孕绒毛 NF-κB表达降低，可能是米非司酮终止早孕的机理之一

关键词: 核转录因子-κB；绒毛；细胞滋养层；米非司酮；绒毛间质

Abstract:

Objective To probe into the effect of mifepirstone on expression of nuclear factor-κB（NF-κB） in human villi during the early pregnancy. Methods Expression of NF-κB was detected in human villi of 18 surgical abortion women and 22 medical abortion women by RT-PCR and immunohistochemical analysis. Results Expression of NF-κB mRNA in villi of the medical abortion group was significantly weaker when compared with that of the surgical abortion group(P＜0.01)，and expression of NF-κB protein in cytotrophoblasts of the medical abortion group was significantly weaker when compared with that of the surgical abortion group(P＜0.05). Conclusions Decreased expression of NF-κB in human villi induced by mifepristone may be one of the mechanisms for terminating early pregnancy.

Key words: Nuclear factor-κB； Villi； Cytotrophoblasts； Mifepristone； Villous stromal

中图分类号:

R714

郑晓静，孙颖，刘姝，赵兴波，李明江. 米非司酮对人早孕绒毛组织核转录因子-κB表达的影响[J]. 山东大学学报(医学版), 2010, 48(1): 106-.

ZHENG Xiaojing， SUN Ying， LIU Shu， ZHAO Xingbo， LI Mingjiang. Effect of mifepristone on expression of nuclear factor-κB in human villi during early pregnancy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(1): 106-.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed