氨茶碱/壳聚糖/β环糊精肺部缓释微球对呼吸道粘膜的影响

山东大学学报(医学版) ›› 2009, Vol. 47 ›› Issue (9): 21-24.

氨茶碱/壳聚糖/β环糊精肺部缓释微球对呼吸道粘膜的影响

张小茜¹,张竞竞²,张维芬²

潍坊医学院 1. 临床学院内科学教研室, 山东潍坊 261031； 2. 基础学院药理学教研室, 山东潍坊 261053

收稿日期:2009-01-19 发布日期:2009-09-16
通讯作者: 张维芬(1966- )，副教授，主要从事药物新剂型方面的研究。 Email:zwf2024@126.com
作者简介:张小茜(1970- )，女，讲师，硕士，主要从事内科学及临床药理学方面的研究。Email：zhangxiaoqian910@yahoo.com.cn
基金资助:
山东省自然科学基金资助项目（Y2008F15）；潍坊医学博士基金资助项目(KB200704)。

Mucociliotoxicity of theophylline/chitosan/βcyclodextrin 
microspheres as a sustained pulmonary delivery

ZHANG Xiaoqian¹, ZHANG Jingjing², ZHANG Weifen²

. Department of Medicine, Clinic Institute, Weifang Medical Univers ity, Weifang 261031, Shandong, China; 
2. Department of Pharmacology, Elementary Institute, Weifang Medical University, Weifang 261053, Shandong, China

Received:2009-01-19 Published:2009-09-16

摘要/Abstract

摘要：

目的探讨氨茶碱/壳聚糖/β环糊精微球肺部缓释微球的呼吸道粘膜毒性。方法通过测定氨茶碱/壳聚糖/β环糊精微球肺部给药后肺泡灌洗液乳酸脱氢酶活性和总蛋白及纤毛毒性实验,对其安全性进行评价。结果氨茶碱/壳聚糖/β环糊精微球的纤毛持续运动时间为512.33?min,纤毛运动频率为96.0%,表明其有良好的生理适应性;氨茶碱/壳聚糖/β环糊精微球气管给药后总蛋白含量增加,乳酸脱氢酶（LDH）活性与正常组和阴性对照组差异不明显。结论氨茶碱/壳聚糖/β环糊精微球对呼吸道粘膜无明显毒性,可作为肺部给药载体。

关键词: 氨茶碱, 壳多糖, 微球体, 生物相容性

Abstract:

To explore mucociliotoxicity of theophylline/chitosan/βcyclodextrin microspheres as pulmonary sustained drug delivery carriers. MethodsAn acute cell toxicity experiment (LDH and protein in BALF) and a mucociliotoxicity experiment were carried out. ResultsCiliary movement time of MS B microspheres was 512.33 minutes and ciliary beat frequency was 96.0%. The total contents of protein and LDH in BALF of the pulmonary delivery group were not significantly different from those of the control group. ConclusionThese results indicated microspheres possessed better adaptability. 

Key words: Aminophylline; Chitin; Microspheres; Biocompability

中图分类号:

R944

. 氨茶碱/壳聚糖/β环糊精肺部缓释微球对呼吸道粘膜的影响[J]. 山东大学学报(医学版), 2009, 47(9): 21-24.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed