微创血肿清除术对脑出血患者血清胶质纤维酸性蛋白的影响

山东大学学报(医学版) ›› 2009, Vol. 47 ›› Issue (9): 122-124.

微创血肿清除术对脑出血患者血清胶质纤维酸性蛋白的影响

崔元孝¹，迟兆富¹，张清华²，于兆昂², 亓勤德³

山东大学 1. 齐鲁医院神经内科，济南 250012； 
2. 附属山东省立医院神经内科，济南 250021；
3. 莱芜市人民医院神经内科，山东莱芜 271100

收稿日期:2009-06-25 发布日期:2009-09-16
通讯作者: 迟兆富（1948- ）男，教授，博导，主要从事脑血管病及癫痫的研究。
作者简介:崔元孝（1966- ）男,主任医师, 博士研究生，主要从事脑血管病及癫痫的研究。Email:cyx603@yahoo.com.cn
基金资助:
山东省自然科学基金资助项目（Y2006C79）。

Effect of miniinvasive hematoma aspiration on the content of glial

fibrillary acidic protein in patients with cerebral hemorrhage

CUI Yuanxiao¹, CHI Zhaofu¹，　ZHANG Qinghua², YU Zhaoang², QI Qinde³

1. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, China;
2. Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; 
3. Department of Neurology, Laiwu People′s Hospital, Laiwu 271100, Shandong, China

Received:2009-06-25 Published:2009-09-16

摘要/Abstract

摘要：

目的探讨微创血肿清除术对脑出血患者血清胶质纤维酸性蛋白（GFAP）的影响。方法采用酶联免疫吸附法测定脑出血微创术患者74例、脑出血非手术患者80例发病后1（手术组术前）、3、7、14?d血清胶质纤维酸性蛋白含量,取60名健康查体者作为正常对照组，分析微创术对脑出血患者GFAP水平动态变化的影响。结果脑出血患者发病后各时间点血浆GFAP水平显著高于正常对照组(P均＜0.001), 手术组在第7、14天显著低于非手术组但仍明显高于对照组(P均＜0.001)；两组脑出血患者第1、3、7、14天血清GFAP含量均与当天神经功能缺损评分（NDS）成正相关。结论微创术后血清GFAP 含量显著降低,可作为评价高血压性脑出血微创术治疗效果的生物学指标。

关键词: 穿刺术, 颅内出血，高血压性, 胶质纤维酸性蛋白

Abstract:

To study the concentration of serum glial fibrillary acidic protein（GFAP）in patients with hypertensive cerebral hemorrhage after minimally invasive surgery (MIS). MethodsBlood samples were obtained on day 1 (before the operation in the MIS group), 3, 7, and 14 after the onset in 74 patients with MIS and 80 patients with non minimally invasive surgery (NMIS), and 60 normal controls(the NC group). Serum GFAP was detected by enzyme linked immunosorbent assay(ELISA). ResultsThe content of serum GFAP in the NMIS group significantly increased on day1, rose to a climax on day7, and then decreased, but was still significantly higher than that in the control group. Compared with the NMIS group, the level of serum GFAP in the MIS group significantly decreased on day 7 and 14. GFAP had correlations with nerve function deficiency score (NDS). ConclusionsMiniinvasive hematoma aspiration can decrease the serum level of GFAP in patients with cerebral hemorrhage. Serum GFAP is a potential marker for prognosis and outcome in patients with nonminimally invasive surgery.

Key words: Intracranial hemorrhage, hypertensive; Glial fibrillary acidic protein; Punctures

中图分类号:

R743.34

. 微创血肿清除术对脑出血患者血清胶质纤维酸性蛋白的影响[J]. 山东大学学报(医学版), 2009, 47(9): 122-124.

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